Author

A. J. Koster

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:electronic health records· 2 Research Focus:host-pathogen & immune response· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Assay:imaging· 1 Research Focus:imputation· 1 Research Focus:software / tool· 1

Frequent Co-Authors

M. Barcena· 4 shared E. J. Snijder· 3 shared G. Wolff· 3 shared R. W. A. L. Limpens· 3 shared S. Zheng· 3 shared A. W. M. de Jong· 2 shared D. Agard· 2 shared F. G. A. Faas· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersMicrobiology

M. Barcena

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4 papers

Recent·Most cited

AreTomo: An integrated software package for automated marker-free, motion-corrected cryo-electron tomographic alignment and reconstruction

S. Zheng, G. Wolff, G. Greenan, Z. Chen, F. G. A. Faas, M. Barcena, A. J. Koster, Y. Cheng, D. Agard

AreTomo automates motion-corrected cryo-electron tomographic alignment and reconstruction, enabling high-resolution subtomogram averaging and real-time feedback during data collection.

bioRxiv · Feb 15, 2022Cell Biology

A molecular pore spans the double membrane of the coronavirus replication organelle

G. Wolff, R. W. A. L. Limpens, J. C. Zevenhoven-Dobbe, U. Laugks, S. Zheng, A. W. M. de Jong, R. I. Koning, D. A. Agard, K. Grünewald, A. J. Koster, E. J. Snijder, M. Barcena

The paper identifies a molecular pore in coronavirus replication organelles that facilitates RNA export to the cytosol, suggesting it as a potential drug target.

bioRxiv · Jun 25, 2020Microbiology

A unifying structural and functional model of the coronavirus replication organelle: tracking down RNA synthesis

E. J. Snijder, R. W. A. L. Limpens, A. H. de Wilde, A. W. M. de Jong, J. C. Zevenhoven-Dobbe, H. J. Maier, F. G. A. Faas, A. J. Koster, M. Barcena

This study identifies double-membrane vesicles (DMVs) as the central site for viral RNA synthesis in coronaviruses, providing a unifying model of the replication organelle.

bioRxiv · Mar 24, 2020Microbiology

Mind the gap: micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae

G. Wolff, R. W. A. L. Limpens, S. Zheng, E. J. Snijder, D. Agard, A. J. Koster, M. Barcena

This paper introduces micro-expansion joints to reduce lamella bending during cryo-FIB-milling, improving structural studies of biological samples.

bioRxiv · May 31, 2019Microbiology