Author

A. J. Layton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. Franklin· 2 shared A. L. Lovering· 2 shared E. C. Lowe· 2 shared P. J. Moynihan· 2 shared S. J. Williams· 2 shared S. T. Benedict· 2 shared A. Basle· 1 shared A. Cartmell· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

A. Franklin

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Author profile →

2 papers

Recent·Most cited

The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth

A. Franklin, A. J. Layton, T. Mize, V. C. Salgueiro, R. Sullivan, S. T. Benedict, S. S. Gurcha, I. Anso, G. S. Besra, M. Banzhaf, A. L. Lovering, S. J. Williams, M. E. Guerin, N. E. Scott, R. Prados-Rosales, , P. J. Moynihan

This study identifies LamH, a glycoside hydrolase that cleaves -1,6-mannoside linkages in LAM/LM, enabling their export to the capsule and promoting bacterial growth.

bioRxiv · Oct 26, 2023Microbiology

Mining the human gut microbiome identifies mycobacterial D-arabinan degrading enzymes

O. Al-Jourani, S. T. Benedict, J. Ross, A. J. Layton, P. van der Peet, V. Marando, N. P. Bailey, T. Heunis, J. Manion, F. Mensitieri, A. Franklin, J. Abellon-Ruiz, S. L. Oram, L. Parsons, A. Cartmell, , P. J. Moynihan

The paper identifies D-arabinan degrading enzymes in the human gut microbiome, including new families of glycoside hydrolases and mycobacterial enzymes involved in cell wall degradation.

bioRxiv · Jul 22, 2022Biochemistry