Author

G. S. Besra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

N. Veerapen· 3 shared A. L. Lovering· 2 shared P. J. Moynihan· 2 shared A. Aulicino· 1 shared A. D. H. Kingdon· 1 shared A. Franklin· 1 shared A. J. Layton· 1 shared A. Lloyd· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersCancer Biology

N. Veerapen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth

A. Franklin, A. J. Layton, T. Mize, V. C. Salgueiro, R. Sullivan, S. T. Benedict, S. S. Gurcha, I. Anso, G. S. Besra, M. Banzhaf, A. L. Lovering, S. J. Williams, M. E. Guerin, N. E. Scott, R. Prados-Rosales, , P. J. Moynihan

This study identifies LamH, a glycoside hydrolase that cleaves -1,6-mannoside linkages in LAM/LM, enabling their export to the capsule and promoting bacterial growth.

bioRxiv · Oct 26, 2023Microbiology

Conserved allomorphs of MR1 drive specificity of MR1-restricted TCRs

T. V. Cornforth, N. A. Moyo, S. Cole, E. Lam, T. Lobry, R. Wolchinsky, A. Lloyd, K. Ward, E. M. Denham, G. S. Besra, N. Veerapen, P. T. Illing, J. P. Vivian, J. M. Raynes, J. Le Nours, , J. Dukes

The paper shows that MR1-restricted TCRs recognize an allelic variant of MR1 (MR1*04) present in healthy individuals, indicating that these TCRs are not cancer-specific and may react to both cancer and healthy cells.

bioRxiv · Jul 17, 2023Cancer Biology

Repurposing Vanoxerine as a new antimycobacterial drug and its impact on the mycobacterial membrane

A. D. H. Kingdon, A.-R. Meosa John, S. M. Batt, G. S. Besra

This study identifies vanoxerine as an antimycobacterial agent that disrupts mycobacterial membrane potential, inhibits efflux, and shows no resistance, supporting its development for tuberculosis treatment.

bioRxiv · Nov 29, 2022 · PreprintMicrobiology

African Salmonella Typhimurium sequence type 313 lineage 2 evades MAIT cell recognition by overexpressing RibB

L. Preciado-Llanes, A. Aulicino, R. Canals, P. Moynihan, X. Zhu, N. Jambo, T. Nyirenda, I. Kadwala, S. V. Owen, N. Veerapen, G. S. Besra, M. A. Gordon, J. C. D. Hinton, G. Napolitani, M. Salio, A. Simmons

The paper shows African S. Typhimurium lineage 2 strains evade MAIT cell recognition by overexpressing ribB, which may contribute to their pathogenicity.

bioRxiv · Sep 10, 2019Immunology

The hydrolase LpqI primes mycobacterial peptidoglycan recycling.

P. J. Moynihan, I. T. Cadby, N. Veerapen, M. Jankute, M. Crosatti, G. Mukamolova, A. L. Lovering, G. S. Besra

This study shows that Mycobacterium tuberculosis and M. bovis BCG recycle peptidoglycan via the LpqI enzyme, which is essential for amino sugar recycling and affects antimicrobial resistance.

bioRxiv · Jul 4, 2018Microbiology