Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
J. B. White, A. Silale, M. C. Feasey, T. Heunis, Y. Zhu, H. Zheng, A. Gajbhiye, S. Firbank, A. Basle, M. Trost, D. N. Bolam, N. A. Ranson, B. van den Berg
The paper identifies utilisomes as stable glycan-utilising complexes in Bacteroides thetaiotaomicron, revealing their structure and mechanism of substrate capture via cryo-EM.
bioRxiv · Aug 15, 2022Microbiology
C. Bussi, T. Heunis, E. Pellegrino, E. M. Bernard, N. Bah, M. Silva Dos Santos, P. Santucci, B. Aylan, A. Rodgers, A. Fearns, J. Mitschke, C. Moore, J. I. MacRae, M. Greco, T. Reinheckel, , M. G. Gutierrez
This study shows lysosomal damage leads to mitochondrial proteome changes and metabolic reprogramming in macrophages, affecting immune responses to infections.
bioRxiv · Aug 9, 2022Cell Biology
O. Al-Jourani, S. T. Benedict, J. Ross, A. J. Layton, P. van der Peet, V. Marando, N. P. Bailey, T. Heunis, J. Manion, F. Mensitieri, A. Franklin, J. Abellon-Ruiz, S. L. Oram, L. Parsons, A. Cartmell, , P. J. Moynihan
The paper identifies D-arabinan degrading enzymes in the human gut microbiome, including new families of glycoside hydrolases and mycobacterial enzymes involved in cell wall degradation.
bioRxiv · Jul 22, 2022Biochemistry
E. Buzun, T. Heunis, C. Cottam, M. Trost, E. C. Lowe
The paper shows that Bacteroides salyersiae uses the Type 9 Secretion System to release manno-oligosaccharides from mannan, which can be used by other Bacteroides species.
bioRxiv · Jul 15, 2022 · PreprintMicrobiology
O. Bilkei-Gorzo, T. Heunis, J.-L. Marin Rubio, F. R. Cianfanelli, B. B. A. Raymond, J. Inns, D. Fabrikova, J. Peltier, F. Oakley, R. Schmid, A. Härtlova, M. Trost
This study identifies RNF115 as an E3 ligase that regulates phagosomal maturation and host response to bacterial infection through ubiquitylation.
bioRxiv · Jul 13, 2021Biochemistry
J. L. Marin-Rubio, R. E. Heap, T. Heunis, M. E. Duenas, J. Inns, J. Scott, A. J. Simpson, J. M. Allan, H. Blair, O. Heidenreich, B. Saxty, M. Trost
This study identifies nilotinib as an anti-inflammatory drug using a MALDI-TOF assay in AML-derived monocytes, showing it inhibits the p38-MK2/3 signaling axis.
bioRxiv · Mar 29, 2021 · PreprintCancer Biology
R. E. Heap, J. L. Marin Rubio, J. Peltier, T. Heunis, A. Dannoura, A. Moore, M. Trost
The paper characterizes L929 cell supernatant proteome and shows it induces a stronger anti-inflammatory M1 phenotype in BMDMs compared to M-CSF alone.
bioRxiv · Aug 20, 2020Immunology
C. J. Queval, A. Fearns, L. Botella, A. Smyth, L. Schnettger, M. Mitermite, E. Wooff, B. Villareal-Ramos, W. Garcia-Gimenez, T. Heunis, M. Trost, D. Werling, F. J. Salguero, S. V. Gordon, M. Gutierrez
This study compares macrophage responses to human- and animal-adapted tuberculosis pathogens, identifying factors that drive multinucleated cell formation in bovine macrophages infected with M. bovis.
bioRxiv · Jul 2, 2020Microbiology
T. Heunis, F. Lamoliatte, J.-L. Marin Rubio, A. Dannoura, M. Trost
The paper quantifies ubiquitin chain types in murine tissues using optimized Ub-AQUA-PRM, revealing tissue-specific differences and enrichment of atypical K33 chains in contractile tissues.
bioRxiv · Mar 18, 2020Biochemistry