Author

A. Cartmell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:human· 4 Assay:proteomics· 3 Assay:metagenomics· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Basle· 4 shared D. P. Byrne· 4 shared E. A. Yates· 4 shared A. S. Luis· 2 shared E. C. Martens· 2 shared G. C. Hansson· 2 shared G. S. Wright· 2 shared J. A. London· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersBiochemistry

A. Basle

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Author profile →

6 papers

Recent·Most cited

Arylsulfamates inhibit colonic Bacteroidota growth through a sulfatase-independent mechanism

A. cartmell, C. J. Crawford, C. W. Tomlinson, C. Gunawan, Z. Chen, D. P. Byrne, C. Darby, M. L. Conti, T. Larson, A. S. J. Luis, S. Elli, E. A. Yates, D. N. Bolam, S. van der Post, S. J. Williams

The paper shows arylsulfamates inhibit Bacteroides growth on sulfated glycans via a lipid kinase, not carbohydrate sulfatases, and identifies resistance mechanisms.

bioRxiv · Apr 27, 2024 · PreprintBiochemistry

Mining the human gut microbiome identifies mycobacterial D-arabinan degrading enzymes

O. Al-Jourani, S. T. Benedict, J. Ross, A. J. Layton, P. van der Peet, V. Marando, N. P. Bailey, T. Heunis, J. Manion, F. Mensitieri, A. Franklin, J. Abellon-Ruiz, S. L. Oram, L. Parsons, A. Cartmell, , P. J. Moynihan

The paper identifies D-arabinan degrading enzymes in the human gut microbiome, including new families of glycoside hydrolases and mycobacterial enzymes involved in cell wall degradation.

bioRxiv · Jul 22, 2022Biochemistry

Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota

A. S. Luis, A. Basle, D. P. Byrne, G. S. Wright, J. London, J. Chunsheng, N. Karlsson, G. C. Hansson, P. A. Eyers, M. Czjzek, T. Barbeyron, E. A. Yates, E. C. Martens, A. Cartmell

This study analyzes carbohydrate sulfatases from Bacteroides thetaiotaomicron, correlating structural and functional data with phylogenetic and environmental analyses to understand sulfated glycan metabolism.

bioRxiv · Jul 23, 2021Biochemistry

Insights into glycan import by a prominent gut symbiont

D. Gray, J. White, A. Oluwole, P. Rath, A. Glenwright, A. Mazur, M. Zahn, A. Basle, C. Morland, S. Evans, A. Cartmell, C. V. Robinson, S. Hiller, N. Ranson, D. Bolam, B. van den Berg

This study characterizes the SusCD protein complex in Bacteroides thetaiotaomicron to elucidate its role in glycan uptake, revealing structural and functional insights into ligand binding and transport dynamics.

Nature Communications · Jan 4, 2021Peer-reviewedMicrobiology

Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity.

D. P. Byrne, J. A. London, P. A. Eyers, E. A. Yates, A. Cartmell

This study develops a rapid capillary electrophoresis assay for quantifying carbohydrate desulfation by sulfatases, demonstrating its advantages over existing methods.

bioRxiv · Dec 1, 2020Biochemistry

A single bacterial sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium

A. S. Luis, C. Jin, G. Vasconcelos Pereira, R. W. P. Glowacki, S. Gugel, S. Singh, D. P. Byrne, N. A. Pudlo, J. A. London, A. Basle, M. Reihill, S. Oscarson, P. Eyers, M. Czjzek, G. Michel, , E. C. Martens

This study identifies a single sulfatase essential for colonic mucin O-glycan metabolism and intestinal colonization by Bacteroides thetaiotaomicron.

bioRxiv · Nov 20, 2020 · PreprintMicrobiology