Author

S. A. Clark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Coscia· 2 shared J. Abraham· 2 shared J. Pan· 2 shared L. E. Clark· 2 shared A. Adamo· 1 shared A. Castor· 1 shared A. Cotton· 1 shared A. Enshaei· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

A. Coscia

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A

C. K. Brierley, B. H. Yip, G. Orlando, H. Goyal, S. Wen, J. Wen, M. F. Levine, M. G. Jakobsdottir, A. Rodriguez-Meira, A. Adamo, M. Bashton, A. Hamblin, S. A. Clark, J. O'Sullivan, L. Murphi, , A. J. Mead

The paper identifies chromothripsis-induced amplification of DYRK1A in blast phase MPN as a driver of aggressive disease and a potential therapeutic target.

bioRxiv · Dec 8, 2023 · PreprintCancer Biology

Structural basis for VLDLR recognition by eastern equine encephalitis virus

P. Yang, W. Li, X. Fan, J. Pan, C. J. Mann, H. Varnum, L. E. Clark, S. A. Clark, A. Coscia, K. N. Smith, V. Brusic, J. Abraham

This study determines the structures of EEEV and SFV spike glycoproteins bound to VLDLR, revealing distinct binding modes that explain how different alphaviruses use the same receptor.

bioRxiv · Nov 14, 2023Microbiology

Rewiring of the host cell metabolome and lipidome during lytic gammaherpesvirus infection is essential for infectious virus production

S. A. Clark, A. Vazquez, K. Furiya, M. K. Splattstoesser, A. K. Bashmail, H. Schwartz, M. Russell, S.-J. Bhark, O. K. Moreno, M. McGovern, E. R. Owsley, T. A. Nelson, E. Sanchez, T. Delgado

This study identifies metabolic rewiring in host cells during gammaherpesvirus infection, showing that glucose, glutamine, and lipid metabolism are essential for viral production.

Journal of Virology · Jun 29, 2023Peer-reviewedMicrobiology

Complex genotype-phenotype relationships shape the response to treatment of Down Syndrome Childhood Acute Lymphoblastic Leukaemia

C. Lutz, V. A. Turati, R. Clifford, P. S. Woll, T. Stiehl, A. Castor, S. A. Clark, H. Ferry, V. Buckle, A. Trumpp, A. Ho, A. Marciniak-Czochra, J. Herrero, A. Schuh, S. E. W. Jacobsen, T. Enver

This study investigates genotype-phenotype relationships in Down Syndrome ALL, showing that genetic and phenotypic heterogeneity influences treatment response and relapse through clonal competition.

bioRxiv · Feb 6, 2022Cancer Biology

Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2

S. A. Clark, L. E. Clark, J. Pan, A. Coscia, L. G. A. McKay, S. Shankar, R. I. Johnson, A. Griffiths, J. Abraham

The paper identifies germline-biased neutralizing antibodies against SARS-CoV-2 and shows that affinity gains do not always correlate with neutralization potency.

bioRxiv · Nov 13, 2020Microbiology

Topologically correct synthetic reconstruction of pathogen social behavior found in deep tissue sites

S. A. Clark, D. Thibault, L. M. Shull, K. M. Davis, E. Aunins, T. van Opijnen, R. R. Isberg

The paper reconstructs microbial social behavior in deep tissue sites using microfluidics-driven microdroplets and NO generation, mimicking spatial regulation observed in tissues.

bioRxiv · Apr 27, 2020Microbiology