A. K. Brown

CryoEM structure of the di-domain core of Mycobacterium tuberculosis polyketide synthase 13, essential for mycobacterial mycolic acid synthesis.

This paper reports the cryoEM structure of M. tuberculosis Pks13, revealing its homodimeric architecture and providing insights into its catalytic mechanism.

Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathway

This study identifies the CD36-PKM2-mtROS pathway as a mechanism by which oxidized LDL disrupts efferocytosis, contributing to atherosclerosis progression.

Integrative multi-omics analysis reveals conserved hierarchical mechanisms of FOXO3 pioneer-factor activity

This study identifies FOXO3's chromatin-level mechanisms in human cells, revealing a two-step pioneer activity and novel regulatory networks involved in aging-related processes.

Infanticide by females is a leading source of juvenile mortality in a large social carnivore

The paper quantifies infanticide's role in juvenile mortality among wild spotted hyenas, finding it accounts for 24% of deaths and supports the hypothesis of social status competition as its evolutionary driver.