Author

A. W. Orr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pathology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. Wang· 2 shared J. G. Traylor· 2 shared A. Gupta· 1 shared A. K. Brown· 1 shared B. C. Smith· 1 shared B. G. Coon· 1 shared B. G. Petrich· 1 shared B. H. Pearson· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersPathology

D. Wang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Gamma protocadherins in vascular endothelial cells inhibit Klf2/4 to promote atherosclerosis

D. Joshi, B. G. Coon, R. Chakraborty, H. Deng, P. Fernandez Tussy, E. Meredith, J. G. Traylor, A. W. Orr, C. Fernandez-Hernando, M. A. Schwartz

This study identifies Pcdhg as a suppressor of Klf2/4 in endothelial cells, promoting atherosclerosis by inhibiting the Notch pathway.

bioRxiv · Jan 16, 2024 · PreprintCell Biology

CD14 Blockade Does Not Improve Outcomes of Deep Vein Thrombosis Following Inferior Vena Cava Stenosis in Mice

N. Pandey, H. Kaur, L. Chandaluri, S. K. Anand, H. Chokhawala, T. Magdy, K. Stokes, A. W. Orr, O. Rom, N. Dhanesha

This study investigates whether CD14 blockade improves DVT outcomes after IVC stenosis in mice, finding no significant effect on thrombus weight, incidence, or neutrophil recruitment.

bioRxiv · Jan 10, 2024 · PreprintPathology

Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathway

J. Zhang, J. Chang, V. Chen, M. A. Beg, W. Huang, L. Vick, Y. Wang, H. Zhang, E. Yttre, A. Gupta, M. Castleberry, Z. Zhang, W. Dai, S. Song, J. Zhu, , Y. Chen

This study identifies the CD36-PKM2-mtROS pathway as a mechanism by which oxidized LDL disrupts efferocytosis, contributing to atherosclerosis progression.

bioRxiv · Sep 7, 2023 · PreprintImmunology

Selective role of Nck1 in atherogenic inflammation and plaque formation

M. Alfaidi, C. H. Acosta, D. Wang, J. G. Traylor, A. W. Orr

This study identifies Nck1's role in flow-induced endothelial activation and atherosclerosis by showing its necessity for IRAK-1 activation and inflammation.

bioRxiv · Apr 6, 2020Pathology

Integrin Affinity Modulation Critically Regulates Atherogenic Endothelial Activation in vitro and in vivo

Z. Al Yafeai, J. M. Peretik, B. H. Pearson, U. Bhattarai, D. Wang, B. G. Petrich, A. W. Orr

This study shows that integrin affinity modulation is critical for endothelial activation in response to atheroprone hemodynamics and oxidized lipoproteins, with talin1 L325R mutations impairing this process.

bioRxiv · Feb 14, 2020Cell Biology