Author

A. K. Cain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. Parkhill· 3 shared L. Barquist· 2 shared A. Filloux· 1 shared A. J. Westermann· 1 shared B. A. Eijkelkamp· 1 shared B. Qualmann· 1 shared C. A. McDevitt· 1 shared C. Boyer· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersMicrobiology

J. Parkhill

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A synthetic peptide mimic kills Candida albicans and synergistically prevents infection

S. Schaefer, R. Vij, J. L. Sprague, S. Austermeier, H. Dinh, P. R. Judzewitsch, E. Seemann, B. Qualmann, A. K. Cain, N. Corrigan, M. S. Gresnigt, C. Boyer, M. D. Lenardon, S. Brunke

This study identifies synthetic peptide mimics that kill Candida albicans and synergize with caspofungin to prevent infection, showing efficacy in vitro and in vivo without resistance development.

bioRxiv · Sep 25, 2023Microbiology

High-throughput transposon mutagenesis in the family Enterobacteriaceae reveals core essential genes and rapid turnover of essentiality

F. Ashari Ghomi, G. Langridge, A. K. Cain, C. J. Boinett, M. Abd El Ghany, D. J. Pickard, R. A. Kingsley, N. Thomson, J. Parkhill, P. P. Gardner, L. Barquist

The paper uses transposon mutagenesis across Enterobacteriaceae species to identify core essential genes and shows rapid turnover of essentiality across related strains.

bioRxiv · Oct 20, 2022Microbiology

The molecular basis of Acinetobacter baumannii cadmium toxicity and resistance

S. F. Alquethamy, F. G. Adams, R. Maharjan, N. N. Delgado, M. Zang, J. C. Paton, K. A. Hassan, I. T. Paulsen, C. A. McDevitt, A. K. Cain, B. A. Eijkelkamp

This study identifies CzcE and the CzcCBA efflux system as key factors in A. baumannii's resistance to cadmium stress and reveals metal ion homeostasis changes under cadmium exposure.

bioRxiv · Oct 20, 2020Microbiology

A global data-driven census of Salmonella small proteins and their potential functions in bacterial virulence

E. Venturini, S. L. Svensson, S. Maass, R. Gelhausen, F. Eggenhofer, L. Li, A. K. Cain, J. Parkhill, D. Becher, R. Backofen, L. Barquist, C. M. Sharma, A. J. Westermann, J. Vogel

The paper identifies and characterizes small proteins in Salmonella Typhimurium using integrated omics data, revealing a new role for MgrB in virulence and motility.

bioRxiv · May 26, 2020Microbiology

Discovery of a Pseudomonas aeruginosa Type VI secretion system toxin targeting bacterial protein synthesis using a global genomics approach

L. M. Nolan, A. K. Cain, E. Manoli, M. A. Sainz-Polo, G. Dougan, D. A. I. Mavridou, D. Albesa-Jove, J. Parkhill, A. Filloux

The paper uses TraDIS to identify T6SS toxins in Pseudomonas aeruginosa, finding Tse8 targets bacterial protein synthesis by disrupting the transamidosome complex.

bioRxiv · Aug 13, 2019 · PreprintMicrobiology