Author

R. Backofen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Approach:experimental assay· 7 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Organism:C. elegans· 3 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

C. Steglich· 3 shared F. Heyl· 3 shared W. R. Hess· 3 shared A. Wilde· 2 shared D. Becher· 2 shared L. Barquist· 2 shared R. Gelhausen· 2 shared S. Maass· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

C. Steglich

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Ribosome profiling reveals the fine-tuned response of Escherichia coli to mild and severe acid stress

K. Schumacher, R. Gelhausen, W. Kion-Crosby, L. Barquist, R. Backofen, K. Jung

This study uses ribosome profiling and RNA sequencing to analyze E. coli's response to mild and severe acid stress, identifying new genes, pathways, and sORFs.

bioRxiv · Jun 2, 2023 · PreprintMicrobiology

The role of the 5' sensing function of ribonuclease E in cyanobacteria

U. A. Hoffmann, E. Lichtenberg, S. N. Rogh, R. Bilger, V. Reimann, F. Heyl, R. Backofen, C. Steglich, W. R. Hess, A. Wilde

This study investigates the role of 5' sensing in RNase E of Synechocystis, identifying cleavage sites and demonstrating its impact on rRNA, tRNA maturation, and plasmid copy number.

bioRxiv · Jan 13, 2023Microbiology

Genome wide CRISPR screen for Pasteurella multocida toxin (PMT) binding proteins reveals LDL Receptor Related Protein1 (LRP1) as crucial cellular receptor

G. Schmidt, J. Schoellkopf, T. Mueller, L. Hippchen, T. Mueller, S. Grossmann, R. Reuten, R. Backofen, N. Klugbauer, J. Orth

The paper identifies LRP1 as a critical receptor for PMT toxin entry into cells using a CRISPR screen, showing its role in toxin binding and G protein activation.

bioRxiv · Aug 4, 2022Pharmacology & Toxicology

TREK-1 knock-down in human atrial fibroblasts leads to a myofibroblastic phenotype: a role in phenoconversion and overview of mechano-sensitive channel mRNA expression in cardiac diseases.

E. Darkow, D. Yusuf, S. Rajamani, R. Backofen, P. Kohl, U. Ravens, R. Peyronnet

bioRxiv · Jul 21, 2022 · PreprintCell Biology

Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome

E. Neuwirt, G. Magnani, T. Cikovic, A. Kostina, S. Wohrle, S. Flemming, N. J. Fischenich, B. S. Saller, O. Gorka, S. Renner, C. Agarinis, C. Parker, A. Boettcher, C. J. Farady, R. Backofen, , O. Gross

A small molecule screen identifies tyrosine kinase inhibitors that cause lysosomal damage, leading to cell lysis and NLRP3 inflammasome activation via K+ efflux.

bioRxiv · Feb 19, 2022 · PreprintImmunology

Transcriptome-wide in vivo mapping of cleavage sites for the compact cyanobacterial ribonuclease E reveals insights into its function and substrate recognition

U. A. Hoffmann, F. Heyl, S. N. Rogh, T. Wallner, R. Backofen, W. R. Hess, C. Steglich, A. Wilde

The paper maps RNase E cleavage sites in Synechocystis sp. PCC 6803 using TIER-seq, revealing cleavage signatures and regulatory roles of RNase E and RNase J.

bioRxiv · Jul 27, 2021Microbiology

CdrS is a global transcriptional regulator influencing cell division in Haloferax volcanii

Y. Liao, V. Vogel, S. Hauber, J. Bartel, O. S. Alkhnbashi, S. Maass, T. S. Schwarz, R. Backofen, D. Becher, I. G. Duggin, A. Marchfelder

This study identifies CdrS as a transcriptional regulator essential for cell division in Haloferax volcanii, showing it influences metabolism, protein degradation, and cell division genes.

bioRxiv · May 11, 2021Microbiology

The temperature-regulated DEAD-box RNA helicase CrhR interactome: Autoregulation and photosynthesis-related transcripts

A. Migur, F. Heyl, J. Fuss, A. Srikumar, B. Huettel, C. Steglich, J. S. S. Prakash, R. Reinhardt, R. Backofen, G. W. Owttrim, W. R. Hess

This study identifies the RNA interactome of the cyanobacterial DEAD-box helicase CrhR, revealing its role in photosynthesis and redox regulation through auto-regulation and binding of photosynthesis-related transcripts.

bioRxiv · Mar 26, 2021Plant Biology

A global data-driven census of Salmonella small proteins and their potential functions in bacterial virulence

E. Venturini, S. L. Svensson, S. Maass, R. Gelhausen, F. Eggenhofer, L. Li, A. K. Cain, J. Parkhill, D. Becher, R. Backofen, L. Barquist, C. M. Sharma, A. J. Westermann, J. Vogel

The paper identifies and characterizes small proteins in Salmonella Typhimurium using integrated omics data, revealing a new role for MgrB in virulence and motility.

bioRxiv · May 26, 2020Microbiology