J. C. Paton

Adapting the endoplasmic reticulum proteostasis rescues epilepsy-associated NMDA receptor variants

This study shows that enhancing ER proteostasis with BIX rescues the function of epilepsy-linked NMDAR variants by improving their folding and trafficking.

Inflammatory cytokines rewire the proinsulin interaction network in human islets

This study identifies how inflammatory cytokines alter the proinsulin interactome in human islets, revealing new interactions and mechanisms involved in diabetes-related proinsulin dysregulation.

A phasevarion controls multiple virulence traits, including expression of vaccine candidates, in Streptococcus pneumoniae

This study shows that the SpnIII phasevarion in S. pneumoniae affects multiple virulence traits and vaccine candidate expression, highlighting its importance in vaccine design.

To make or take: bacterial lipid homeostasis during infection

This study investigates how Acinetobacter baumannii balances fatty acid synthesis and acquisition in different host niches during infection.

N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease.

This study measures Neu5Gc serum biomarker levels in breast cancer patients and finds elevated levels at all disease stages, with high sensitivity and specificity for detection.

The molecular basis of Acinetobacter baumannii cadmium toxicity and resistance

This study identifies CzcE and the CzcCBA efflux system as key factors in A. baumannii's resistance to cadmium stress and reveals metal ion homeostasis changes under cadmium exposure.

Endoplasmic reticulum stress induces a novel Ca2+ signalling system initiated by Ca2+ microdomains

The paper identifies a novel Ca2+ signalling system in ER stress initiated by Ca2+ microdomains in human astrocytes and IP3R-deficient cells.

Developmentally regulated PERK activity renders dendritic cells insensitive to subtilase cytotoxin-induced integrated stress response

The paper shows dendritic cells have high eIF2 phosphorylation due to PERK activation, but this does not lead to chronic ISR or translation arrest, allowing them to adapt to stress.

Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

The paper maps interactions of ER ubiquitin ligases and identifies a complex involving RNF26 that modulates innate immune signaling via the cGAS-STING pathway.

The interdomain helix between the kinase and RNase domains of IRE1α transmits the conformational change that underlies ER stress-induced activation.

This study identifies the interdomain helix between IRE1α kinase and RNase domains as critical for transmitting conformational changes during ER stress, revealing its role in regulating oligomerization, RNase activity, and kinase function.

Proteomics identifies signal peptide features determining the substrate specificity in human Sec62/Sec63-dependent ER protein import

In Vivo Dual RNA-Seq Analysis Reveals the Basis for Differential Tissue Tropism of Clinical Isolates of Streptococcus pneumoniae

This study uses dual RNA-seq to show how a single SNP in Streptococcus pneumoniae affects bacterial and host gene expression, leading to differential tissue tropism and disease outcomes.

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

This study shows IRE1β suppresses IRE1α signaling during ER stress by blocking its activation and disrupting a feedback loop that regulates IRE1 expression.