G. Dougan

Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

The paper shows extensive genomic overlap between Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis, including shared genes and recombination events, with implications for vaccine development.

Obesity associated with attenuated tissue immune cell responses in COVID-19

The paper finds that obesity is associated with reduced immune and inflammatory responses in COVID-19 patients, including lower expression of IFN and IFNγ response genes in lung and blood cells.

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

This study identifies EROS as a chaperone essential for gp91phox maturation and P2X7 receptor function, revealing its role in immune responses and infection resistance.

Dissemination and pathogenesis of toxigenic Clostridium perfringens strains linked to neonatal intensive care units and Necrotising Enterocolitis

This study identifies hypervirulent C. perfringens strains linked to NEC in preterm infants, showing their dissemination between hospitals and increased virulence.

FXR inhibition reduces ACE2 expression, SARS-CoV-2 infection and may improve COVID-19 outcome

This study shows FXR inhibition lowers ACE2 expression, reduces SARS-CoV-2 infection, and correlates with better clinical outcomes in COVID-19.

Inhibitory concentrations of ciprofloxacin induce an adaptive response promoting the intracellular survival of Salmonella Typhimurium

This study shows that inhibitory concentrations of ciprofloxacin induce adaptive responses in Salmonella Typhimurium that enhance intracellular survival and replication.

Multiple introductions of multidrug-resistant typhoid associated with acute infection and asymptomatic carriage, Kenya

The study investigates typhoid dynamics in Kenya, finding high multidrug-resistant H58 S. Typhi prevalence in both cases and controls, suggesting carriers contribute to community spread.

Novel gut pathobionts confound results in a widely used mouse model of human inflammatory disease

The paper identifies two novel gut bacteria that influence disease variability in a mouse model of inflammatory bowel disease.

High-content imaging to phenotype antimicrobial effects on individual bacteria at scale

This paper develops a high-throughput high-content imaging method to phenotype bacterial responses to antimicrobials, revealing morphological differences between susceptible and resistant isolates.

Rora regulates activated T helper cells during inflammation

This study investigates Rora's role in CD4+ T cells during inflammation, finding it regulates lung inflammation and is controlled by IL-33 and CCL7.

The genetic signatures of Salmonella Typhi carriage in the human gallbladder

This study sequenced S. Typhi from gallbladder carriers and acute blood isolates, finding higher genetic variability and specific mutations in gallbladder isolates that may contribute to long-term carriage and antigenic variation.

A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131

This study uses high-content imaging to screen a monoclonal antibody against E. coli ST131 isolates, identifying four binding phenotypes and linking them to genetic variations affecting O-antigen structure.

Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

This study identifies prophage-encoded exotoxins in Streptococcus pyogenes that enhance colonization fitness and pathogenesis in scarlet fever.

The RAB32/BLOC-3 dependent pathway mediates host-defence against different pathogens in human macrophages

This study identifies the Rab32/BLOC-3 pathway as a novel host-defense mechanism in macrophages that protects against bacterial and fungal pathogens.

Discovery of a Pseudomonas aeruginosa Type VI secretion system toxin targeting bacterial protein synthesis using a global genomics approach

The paper uses TraDIS to identify T6SS toxins in Pseudomonas aeruginosa, finding Tse8 targets bacterial protein synthesis by disrupting the transamidosome complex.

Genomic analysis on broiler-associated Clostridium perfringens strains and caecal microbiome profiling reveals key factors linked to poultry Necrotic Enteritis

This study identifies hypervirulent Clostridium perfringens strains and microbiome changes associated with necrotic enteritis in broiler chickens.

Phylogenomic analysis of Clostridium perfringens identifies isogenic strains in gastroenteritis outbreaks, and novel virulence-related features

This study uses whole genome sequencing to analyze C. perfringens strains from gastroenteritis outbreaks, identifying isogenic strains and novel virulence features.

Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei

This study identifies genetic determinants of environmental and human adaptation in Burkholderia pseudomallei using genome-wide association studies across clinical and environmental isolates from Thailand and Australia.

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

This study shows that IL-10R signaling in immune cells is essential for controlling whipworm infection, microbiota homeostasis, and preventing immunopathology in mice.