A. K. Lagendijk

Hyaluronic acid turnover controls the severity of Cerebral Cavernous Malformations in bioengineered human micro-vessels

This study shows that HA turnover in ECM affects CCM severity in 3D microfluidic models, independent of KLF2/4.

Macrophages only sense infectious SARS-CoV-2 when they express sufficient ACE2 to permit viral entry, where rapid cytokine responses then limit viral replication.

The paper shows that ACE2-expressing macrophages allow SARS-CoV-2 entry and replication, triggering anti-viral responses, while ACE2-negative macrophages do not support viral entry or cytokine release.

Dynamically regulated Focal adhesions coordinate endothelial cell remodelling in developing vasculature

This study uses zebrafish to show that focal adhesions regulate endothelial cell elongation and junction linearization during vascular development.

Endothelial cells elicit a pro-inflammatory response to SARS-COV-2 without productive viral infection

This study shows that endothelial cells can be infected by SARS-CoV-2 but do not produce infectious virus, instead triggering an inflammatory response through sensing adjacent infections.

Blood vessel occlusion by Cryptococcus neoformans is a mechanism for hemorrhagic dissemination of infection

The paper investigates how Cryptococcus neoformans causes vessel damage and dissemination in zebrafish, finding that vascular growth and stiffness increase dissemination events.