Author

L. I. Labzin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

A. K. Lagendijk· 2 shared K. Schroder· 2 shared T. Esposito· 2 shared X. Wang· 2 shared A. H. Chan· 1 shared A. Rowan· 1 shared B. Hill· 1 shared B. M. Hogan· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCell Biology

A. K. Lagendijk

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Author profile →

3 papers

Recent·Most cited

Hyaluronic acid turnover controls the severity of Cerebral Cavernous Malformations in bioengineered human micro-vessels

T. E. Yordanov, M. A. E. Martinez, T. Esposito, J. B. Tefft, L. I. Labzin, S. J. Stehbens, A. Rowan, B. M. Hogan, C. S. Chen, J. Lauko, A. K. Lagendijk

This study shows that HA turnover in ECM affects CCM severity in 3D microfluidic models, independent of KLF2/4.

bioRxiv · Mar 27, 2023 · PreprintCell Biology

Caspase-4 dimerisation and D289 auto-processing elicits an interleukin-1β converting enzyme

A. H. Chan, K. Vezyrgiannis, J. B. Von Pein, X. Wang, L. I. Labzin, D. Boucher, K. Schroder

This study identifies that caspase-4 dimerisation and D289 auto-processing enable direct cleavage of pro-IL-1β, independent of the NLRP3 inflammasome.

bioRxiv · Jan 5, 2023Immunology

Macrophages only sense infectious SARS-CoV-2 when they express sufficient ACE2 to permit viral entry, where rapid cytokine responses then limit viral replication.

L. I. Labzin, K. Y. Chew, K. Eschke, X. Wang, T. Esposito, C. J. Stocks, J. Rae, R. Patrick, H. Mostafavi, B. Hill, T. Yordanov, C. L. Holley, S. Emming, S. Fritzlar, F. L. Mordant, , K. Schroder

The paper shows that ACE2-expressing macrophages allow SARS-CoV-2 entry and replication, triggering anti-viral responses, while ACE2-negative macrophages do not support viral entry or cytokine release.

bioRxiv · Mar 22, 2022 · PreprintImmunology