T. Yordanov

c-Src induced vascular malformations require localised matrix degradation at focal adhesions

This study shows that c-Src activation in endothelial cells causes vascular expansion through focal adhesion signaling and localized matrix degradation, which can be inhibited to prevent abnormal vascular growth.

Macrophages only sense infectious SARS-CoV-2 when they express sufficient ACE2 to permit viral entry, where rapid cytokine responses then limit viral replication.

The paper shows that ACE2-expressing macrophages allow SARS-CoV-2 entry and replication, triggering anti-viral responses, while ACE2-negative macrophages do not support viral entry or cytokine release.

Endothelial cells elicit a pro-inflammatory response to SARS-COV-2 without productive viral infection

This study shows that endothelial cells can be infected by SARS-CoV-2 but do not produce infectious virus, instead triggering an inflammatory response through sensing adjacent infections.

G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules

This paper shows G3BP1 anchors the TSC complex to lysosomes to suppress mTORC1 signaling without stress granules, and inhibits mTORC1-driven cancer and neuronal issues.