A. M. Leidal

Autophagy cargo receptors are secreted via extracellular vesicles and particles in response to endolysosomal inhibition or impaired autophagosome maturation

This study identifies a secretory autophagy pathway that releases autophagy cargo receptors via extracellular vesicles when endolysosomal function is inhibited or autophagosome maturation is disrupted.

ECM dimensionality tunes actin tension to modulate the endoplasmic reticulum and spheroid phenotype

The paper shows that ECM dimensionality affects actin tension, which in turn modulates endoplasmic reticulum function and spheroid resilience in mammary epithelial cells.