Author

A. Mazzagatti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:whole-genome sequencing· 2 Assay:DNA methylation· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Guyer· 2 shared E. G. Maurais· 2 shared I. Cortes-Ciriano· 2 shared P. Ly· 2 shared Q. Hu· 2 shared B. Bakker· 1 shared D. Bronder· 1 shared D. C. J. Spierings· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

A. Guyer

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Author profile →

3 papers

Recent·Most cited

Non-homologous end joining shapes the genomic rearrangement landscape of chromothripsis from mitotic errors

Q. Hu, J. Espejo Valle-Inclan, R. Dahiya, A. Guyer, A. Mazzagatti, E. G. Maurais, J. L. Engel, I. Cortes-Ciriano, P. Ly

This study shows that non-homologous end joining (NHEJ) is the main pathway causing complex genomic rearrangements during chromothripsis from mitotic errors.

bioRxiv · Aug 10, 2023 · PreprintCell Biology

Mitotic clustering of pulverized chromosomes from micronuclei

Y.-F. Lin, J. E. Valle-Inclan, A. Mazzagatti, Q. Hu, E. G. Maurais, A. Guyer, J. T. Sanders, J. Engel, G. Nguyen, D. Bronder, S. F. Bakhoum, I. Cortes-Ciriano, P. Ly

This study shows that acentric chromosome fragments from micronuclei cluster during mitosis, leading to biased inheritance and balanced chromothripsis in cancer.

Nature · Jun 29, 2023Peer-reviewedCell Biology

Non-Random Mis-Segregation of Human Chromosomes.

J. T. Worrall, N. Tamura, N. Shaikh, A. Mazzagatti, T. van Lingen, B. Bakker, D. C. J. Spierings, E. Vladimirou, F. Foijer, S. E. McClelland

The paper shows that human chromosome mis-segregation is non-random, with specific chromosomes showing higher rates of aneuploidy due to cohesion fatigue.

bioRxiv · Mar 8, 2018Cell Biology