Author

S. F. Bakhoum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 4 Organism:human· 4 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

P. Ly· 2 shared A. Agustinus· 1 shared A. Ali· 1 shared A. D. Amin· 1 shared A. F. Yu· 1 shared A. Friedman· 1 shared A. Guyer· 1 shared A. Luengo· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersCell Biology

P. Ly

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Author profile →

6 papers

Recent·Most cited

Mitotic clustering of pulverized chromosomes from micronuclei

Y.-F. Lin, J. E. Valle-Inclan, A. Mazzagatti, Q. Hu, E. G. Maurais, A. Guyer, J. T. Sanders, J. Engel, G. Nguyen, D. Bronder, S. F. Bakhoum, I. Cortes-Ciriano, P. Ly

This study shows that acentric chromosome fragments from micronuclei cluster during mitosis, leading to biased inheritance and balanced chromothripsis in cancer.

Nature · Jun 29, 2023Peer-reviewedCell Biology

Innate immune signaling drives late cardiac toxicity following DNA damaging cancer therapies

A. Shamseddine, S. Patel, V. Chavez, M. Adnan, M. Di Bona, J. Li, C. T. Dang, L. V. Ramanathan, K. C. Oeffinger, J. E. Liu, R. M. Steingart, A. Piersigilli, N. D. Socci, A. T. Chan, A. F. Yu, , A. M. Schmitt

This study identifies cGAS-STING signaling as a driver of late cardiac toxicity after DNA-damaging cancer therapies and shows that targeting this pathway can mitigate cardiotoxicity.

Journal of Experimental Medicine · Dec 19, 2022Peer-reviewedImmunology

The CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and governs anti-tumor immunity

P. Ho, J. C. Melms, M. Rogava, C. J. Frangieh, S. B. Shah, Z. Walsh, O. Kyrysyuk, A. D. Amin, L. Caprio, B. T. Fullerton, R. Soni, C. R. Ager, J. Biermann, Y. Wang, M. Mu, , B. Izar

The paper identifies the CD58:CD2 axis as co-regulated with PD-L1 via CMTM6 and shows its role in anti-tumor immunity, proposing therapeutic strategies to enhance immunotherapy.

bioRxiv · Mar 21, 2022 · PreprintCancer Biology

Epigenetic dysregulation from chromosomal transit in micronuclei

A. Agustinus, R. Raviram, B. Dameracharla, J. Luebeck, S. Stransky, L. Scipioni, R. Myers, M. DiBona, M. Duran, B. Weigelt, S. Yomtoubian, E. Toufektchan, P. Mischel, V. Mittal, S. Shah, , S. F. Bakhoum

This study shows that chromosomal transit through micronuclei causes epigenetic dysregulation in cancer cells, leading to long-term chromatin accessibility abnormalities.

bioRxiv · Jan 12, 2022Cancer Biology

The clinical and molecular significance associated with STING signaling in estrogen receptor-positive early breast cancer

E. E. Parkes, M. P. Humphries, E. Gilmore, F. A. Sidi, V. Bingham, S. M. Phyu, S. G. Craig, C. Graham, J. Miller, D. Griffin, R. D. Kennedy, S. F. Bakhoum, S. McQuaid, M. Salto-Tellez, N. E. Buckley

The paper identifies perinuclear STING (pnSTING) in ER+ breast cancer as a prognostic marker linked to immune infiltration and poor outcomes in low pnSTING tumors.

bioRxiv · Jul 23, 2020Cancer Biology

Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis

B. Ngo, E. Kim, V. Osorio-Vasquez, S. Doll, S. Bustraan, A. Luengo, S. M. Davidson, A. Ali, G. D. Ferraro, D. Kang, J. Ni, R. Liang, A. Plasger, E. R. Kastenhuber, R. Eskandari, , M. E. Pacold

This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.

bioRxiv · Mar 3, 2020 · PreprintCancer Biology