M. Rosa

Automated Collective Variable Discovery for MFSD2A transporter from molecular dynamics simulations

This paper develops and applies LDA-based methods to identify optimal collective variables from MD simulations of the MFSD2A transporter, improving the classification of metastable states.

Cancer-Associated Mutations Enhance The Sensitivity Of The Trupath GαQ/11 System

The paper modifies Gq and G11 biosensors to enhance sensitivity for detecting Gq/11 activation in GPCRs, including those with cancer-associated mutations.

Breast Cancer Reaction-Diffusion from Spectral-Spatial Analysis in Immunohistochemistry

The paper uses spatial-spectral analysis of immunohistochemistry data to model tumor growth dynamics via reaction-diffusion equations in breast cancer patients.

Structural dynamics of the β-coronavirus Mpro protease ligand binding sites

The paper compares ligand-binding sites of Mpro proteases from SARS-CoV2, SARS-CoV, and MERS-CoV using deep learning and Markov state models to assess structural dynamics and conservation.

Tetraploidy in rodent cardiac stem cells confers enhanced biological properties

The paper compares ploidy in cardiac interstitial cells between rodents and large mammals, finding species-specific differences in tetraploidy and its functional implications.