M. Peng

N-Glycosylation of MRS2 balances aerobic and anaerobic energy production by reducing rapid mitochondrial Mg2+ influx in conditions of high glucose or impaired respiratory chain function

This study shows that N-glycosylation of MRS2, a mitochondrial Mg2+ transporter, regulates Mg2+ influx and balances energy production under high glucose or impaired respiration.

Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes

The paper shows that Spd-2 recruits Polo and Aurora A to form two distinct scaffolds, Cnn-scaffold and TACC-scaffold, which are essential for mitotic centrosome assembly in Drosophila.

Induction of immortal-like and functional CAR-T cells by defined factors

This study identifies factors that induce CAR-T cells with stem-like properties, enhancing their long-term persistence and antitumor efficacy in vivo.

One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice

This paper shows that engineered T cells can cure asthma in mice by targeting eosinophils and blocking inflammatory cytokines.

Genome evolution and transcriptome plasticity associated with adaptation to monocot and eudicot plants in Colletotrichum fungi

This study analyzes genome and transcriptome data from 30 Colletotrichum species to show evolutionary adaptations to monocot and eudicot hosts, including gene expansion and expression changes.

Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia during neurite initiation

This study identifies a septin network that stabilizes filopodia and suppresses lamellipodia during pyramidal neuron morphogenesis, shaping the soma and neurites in vitro and in vivo.

Functional Contribution of Cancer-Associated Fibroblasts in Glioblastoma

This study identifies and characterizes cancer-associated fibroblasts (CAFs) in glioblastoma using single-cell RNA sequencing and spatial transcriptomics, revealing their functional roles in tumor progression and microenvironment interactions.

Molecular Crowding Facilitates Bundling of IMPDH Polymers and Cytoophidium Formation

This study shows that molecular crowding promotes IMPDH polymer bundling and cytoophidium formation, with implications for protein stability and subcellular compartment function.

Emergence of an adaptive epigenetic cell state in human bladder urothelial carcinoma evolution

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

Cell Type Hierarchy Reconstruction via Reconciliation of Multi-resolution Cluster Tree

The paper introduces MRtree, a method to reconstruct cell type hierarchies from scRNA-seq data by reconciling multi-resolution cluster trees, improving upon traditional hierarchical clustering approaches.

Glycolysis Fuels Phosphoinositide 3-Kinase Signaling to Bolster T Cell Immunity

This study shows that glycolysis fuels PI3K signaling in CD8+ T cells, linking metabolic reprogramming to T cell immunity and suggesting therapeutic targets for infectious diseases and cancer.

Individuality, as well as genotype, affects characteristics and temporal consistency of courtship songs in male mice

This study shows that both genotype and individuality influence the composition, complexity, and temporal consistency of courtship songs in male mice.

Fusarium verticillioides FvPex8 is a key component of peroxisomal docking/translocation module that serves important roles in fumonisin biosynthesis but not in virulence

Phase separation-mediated formation of condensed GIT/PIX enzyme complex module for compartmentalized signaling

This study shows that GIT1 and β-Pix form a condensed enzyme complex via phase separation, enabling compartmentalized signaling in different cellular contexts.

PARPi synthetic lethality derives from replication-associated single-stranded DNA gaps

This study shows PARPi sensitivity in BRCA-deficient cells arises from replication-associated ssDNA gaps, not replication speed.

Replication gaps underlie BRCA-deficiency and therapy response

This study challenges the existing model of BRCA-deficiency hypersensitivity to chemotherapy by proposing that ssDNA replication gaps, rather than DNA double strand breaks or stalled forks, underlie the therapeutic response.

Prevention of enteric bacterial infections and modulation of gut microbiota composition with conjugated linoleic acids producing Lactobacillus in mice

This study shows that the probiotic Lactobacillus casei strain LC+mcra reduces Salmonella and EHEC infections in mice by modulating gut microbiota composition and improving gut health.