Author

S. Cantor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:DNA methylation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

K. Cong· 4 shared J. Calvo· 3 shared S. Nayak· 3 shared J. Jonkers· 2 shared J. Krais· 2 shared M. Bere· 2 shared M. Peng· 2 shared N. J. Panzarino· 2 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

K. Cong

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Author profile →

4 papers

Recent·Most cited

Loss of Nuclear DNA Ligase III Reverts PARP Inhibitor Resistance in BRCA1/53BP1 Double-deficient Cells by Exposing ssDNA Gaps

M. Paes Dias, V. Tripathi, I. v. d. Heijden, K. Cong, E.-M. Manolika, J. Bhin, E. Gogola, P. Galanos, S. Annunziato, C. Lieftink, M. Andujar-Sanchez, S. Chakrabarty, G. C. M. Smith, M. v. d. Ven, R. L. Beijersbergen, , J. Jonkers

This study identifies loss of LIG3 as a factor that reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by increasing ssDNA gaps.

bioRxiv · Mar 24, 2021 · PreprintCancer Biology

Replication gaps are a cancer vulnerability counteracted by translesion synthesis

S. Nayak, J. Calvo, K. Cong, E. Berthiaume, J. Jackson, R. C. Dash, A. Vindigni, K. M. Hadden, S. Cantor

The paper identifies that oncogene expression creates replication gaps, which are suppressed by translesion synthesis (TLS), and shows that inhibiting TLS reduces cancer cell fitness.

bioRxiv · Sep 25, 2019Cancer Biology

PARPi synthetic lethality derives from replication-associated single-stranded DNA gaps

K. Cong, A. N. Kousholt, M. Peng, N. J. Panzarino, W. T. C. Lee, S. Nayak, J. Krais, J. Calvo, M. Bere, E. Rothenberg, N. Johnson, J. Jonkers, S. Cantor

This study shows PARPi sensitivity in BRCA-deficient cells arises from replication-associated ssDNA gaps, not replication speed.

bioRxiv · Sep 25, 2019Cancer Biology

Replication gaps underlie BRCA-deficiency and therapy response

N. J. Panzarino, J. Krais, M. Peng, M. Mosqueda, S. Nayak, S. Bond, J. Calvo, K. Cong, M. Doshi, M. Bere, J. Ou, B. Deng, L. J. Zhu, N. Johnson, S. Cantor

This study challenges the existing model of BRCA-deficiency hypersensitivity to chemotherapy by proposing that ssDNA replication gaps, rather than DNA double strand breaks or stalled forks, underlie the therapeutic response.

bioRxiv · Sep 25, 2019Cancer Biology

S. Cantor · henhao