Author

A. O'Garra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:clustering· 1

Frequent Co-Authors

R. J. Wilkinson· 4 shared C. M. Graham· 3 shared A. Mejias· 2 shared C. Bloom· 2 shared D. Chaussabel· 2 shared E. Whalen· 2 shared F. Kheradmand· 2 shared G. Klintmalm· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

R. J. Wilkinson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Blimp-1 and c-Maf regulate common and unique gene networks to protect against distinct pathways of pathobiont-induced colitis

M. Alvarez-Martinez, L. S. Cox, C. F. Pearson, W. J. Branchett, P. Chakravarty, X. Wu, H. Slawinski, A. Al Dibouni, V. Samelis, L. Gabrysova, S. L. Priestnall, A. Suarez-Bonnet, A. Mikolajczak, J. Briscoe, F. Powrie, A. O'Garra

This study shows Blimp-1 and c-Maf regulate gene networks in T cells to prevent colitis, with distinct roles in controlling inflammatory pathways in mouse models.

bioRxiv · Sep 14, 2023 · PreprintImmunology

Development and Characterization of a Fixed Repertoire of Blood Transcriptome Modules Based on Co-expression Patterns Across Immunological States

M. C. Altman, D. Rinchai, N. Baldwin, M. Toufiq, E. Whalen, M. Garand, B. A. Kabeer, M. Alfaki, S. Presnell, P. Khaenam, A. A. Benitez, F. Mougin, P. Thebault, L. Chiche, N. Jourde-Chiche, , D. Chaussabel

The paper develops a fixed repertoire of blood transcriptome modules based on co-expression patterns across immunological states to provide a stable framework for analyzing and interpreting blood transcriptome data.

bioRxiv · Apr 28, 2020Immunology

Transcriptomic characterization of tuberculous sputum reveals a host Warburg effect and microbial cholesterol catabolism

R. P. Lai, T. Cortes, S. Marais, N. Rockwood, M. L. Burke, A. Garza-Garcia, S. Horswell, A. O'Garra, D. B. Young, R. J. Wilkinson

This study uses RNA-sequencing on TB sputum to reveal host metabolic shifts and microbial cholesterol catabolism during tuberculosis transmission.

bioRxiv · Mar 9, 2020Microbiology

A Transcriptome Fingerprinting Assay for Clinical Immune Monitoring

M. C. Altman, N. Baldwin, E. Whalen, T. Al-Shaikhly, S. Presnell, P. Khaenam, V. H. Gersuk, L. Chiche, N. Jourde-Chiche, T. Phillips, G. Klintmalm, A. O'Garra, M. Berry, C. Bloom, R. J. Wilkinson, , D. Chaussabel

The paper develops a targeted transcriptome fingerprinting assay using modular transcriptional repertoires to assess immune functions in clinical settings.

bioRxiv · Mar 24, 2019 · PreprintImmunology

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection

A. Singhania, R. Verma, C. M. Graham, J. Lee, T. Tran, M. Richarsdon, P. Lecine, P. Leissner, M. P. R. Berry, R. J. Wilkinson, K. Kaiser, M. Rodrigue, G. Woltmann, P. Haldar, A. O'Garra

The paper identifies a modular transcriptional signature for active tuberculosis that distinguishes it from latent infection and other diseases, showing dynamic heterogeneity in tuberculosis contacts.

bioRxiv · Jun 5, 2018Immunology