Author

L. Chiche

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 5 Organism:human· 5 Approach:statistical model· 5 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

D. Chaussabel· 3 shared J. Banchereau· 3 shared N. Jourde-Chiche· 3 shared A. Mejias· 2 shared A. O'Garra· 2 shared B. A. Kabeer· 2 shared C. Bloom· 2 shared C. M. Graham· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

D. Chaussabel

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

TREM1+ regulatory myeloid cells expand in steatohepatitis-HCC and associate with poor prognosis and therapeutic resistance to immune checkpoint blockade

J. Giraud, D. Chalopin, E. Ramel, T. Boyer, A. Zouine, M.-A. Derieppe, N. Larmonier, O. Adotevi, B. Le Bail, J.-F. Blanc, L. Chiche, M. Nikolski, M. Saleh

This study identifies TREM1+CD163+ regulatory myeloid cells in steatohepatitis-HCC that suppress T cell function and are linked to poor prognosis and resistance to immune checkpoint therapy.

bioRxiv · Nov 9, 2022 · PreprintImmunology

Development and Characterization of a Fixed Repertoire of Blood Transcriptome Modules Based on Co-expression Patterns Across Immunological States

M. C. Altman, D. Rinchai, N. Baldwin, M. Toufiq, E. Whalen, M. Garand, B. A. Kabeer, M. Alfaki, S. Presnell, P. Khaenam, A. A. Benitez, F. Mougin, P. Thebault, L. Chiche, N. Jourde-Chiche, , D. Chaussabel

The paper develops a fixed repertoire of blood transcriptome modules based on co-expression patterns across immunological states to provide a stable framework for analyzing and interpreting blood transcriptome data.

bioRxiv · Apr 28, 2020Immunology

A Transcriptome Fingerprinting Assay for Clinical Immune Monitoring

M. C. Altman, N. Baldwin, E. Whalen, T. Al-Shaikhly, S. Presnell, P. Khaenam, V. H. Gersuk, L. Chiche, N. Jourde-Chiche, T. Phillips, G. Klintmalm, A. O'Garra, M. Berry, C. Bloom, R. J. Wilkinson, , D. Chaussabel

The paper develops a targeted transcriptome fingerprinting assay using modular transcriptional repertoires to assess immune functions in clinical settings.

bioRxiv · Mar 24, 2019 · PreprintImmunology

Elevation of FAM129A in neutrophils exposed to serum of patients with severe sepsis: in silico investigations during a hands on training workshop and follow on validation of protein expression in neutrophils

J. Roelands, L. Chiche, R. Marches, M. Toufiq, B. A. Kabeer, M. A. I. Alfaki, M. Saadaoui, A. P. Lakshmanan, D. K. Bangarusamy, S. Murugesan, D. Bedognetti, W. Hendrickx, S. A. Khodor, A. Terranegra, J. Banchereau, , D. Rinchai

The paper investigates FAM129A expression in neutrophils exposed to sepsis serum using transcriptome data and confirms surface expression through bench validation.

bioRxiv · Jan 25, 2019 · PreprintImmunology

Serum GlycA level is a candidate biomarker for disease activity in systemic lupus erythematosus and for proliferative status of lupus nephritis, independent of renal function impairment.

T. Dierckx, S. Goletti, L. Chiche, L. Daniel, B. Lauwerys, N. Jourde-Chiche, J. Van Weyenbergh

This study shows Serum GlycA is elevated in systemic lupus erythematosus and correlates with disease activity and lupus nephritis, outperforming traditional biomarkers in predicting proliferative LN.

bioRxiv · Dec 12, 2018 · PreprintImmunology