Author

A. O. Khan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

N. V. Morgan· 3 shared A. Slater· 2 shared J. A. Pike· 2 shared J. Yule· 2 shared S. G. Thomas· 2 shared A. Croft· 1 shared A. J. Murphy· 1 shared A. Maclachlan· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCell Biology

N. V. Morgan

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36

M. N. Barrachina, G. Pernes, I. C. Becker, I. Allaeys, T. I. Hirsch, D. J. Groeneveld, A. O. Khan, D. Freire, K. Guo, E. Carminita, P. K. Morgan, T. J. Collins, N. Mellett, Z. Wei, I. Almazni, , K. R. Machlus

This study identifies the role of phospholipid remodeling and PUFA uptake via CD36 in megakaryopoiesis and platelet production, showing dietary fatty acids impact platelet counts.

bioRxiv · Feb 12, 2023Cell Biology

Human bone marrow organoids for disease modelling, discovery and validation of therapeutic targets in hematological malignancies

A. O. Khan, M. Colombo, J. S. Reyat, G. Wang, A. Rodriguez-Romera, W. X. Wen, L. Murphy, B. Grygielska, C. Mahony, A. Stone, A. Croft, D. C. Bassett, G. Pooligasundarampillai, A. Roy, S. Gooding, , B. Psaila

This paper develops human bone marrow organoids to model hematological malignancies and validate therapeutic targets.

bioRxiv · Mar 14, 2022Cancer Biology

Post-translational polymodification of β1 tubulin regulates motor protein localisation in platelet production and function

A. O. Khan, A. Slater, A. Maclachlan, P. L. Nicolson, J. A. Pike, J. S. S. Reyat, J. Yule, R. Stapley, S. G. Thomas, N. V. Morgan

The paper investigates how post-translational polymodifications of β1 tubulin regulate motor protein localization in platelet production and function using patient data, iPSC-derived megakaryocytes, and platelets.

Haematologica · Dec 17, 2020Peer-reviewedCell Biology

Optimised CRISPR-Cas9 mediated single molecule imaging for accurate quantification through endogenous expression.

A. O. Khan, C. W. White, J. A. Pike, J. Yule, A. Slater, S. J. Hill, N. S. Poulter, S. G. Thomas, N. V. Morgan

This study optimizes CRISPR-Cas9 for single molecule imaging by improving mEos variants and shows endogenous labeling enables accurate quantification of CXCR4.

bioRxiv · Nov 30, 2018 · PreprintCell Biology