Author

S. J. Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Assay:fluorescence / live-cell microscopy· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2

Frequent Co-Authors

C. W. White· 3 shared K. D. Pfleger· 2 shared A. Inoue· 1 shared A. K. Shukla· 1 shared A. O. Khan· 1 shared A. Slater· 1 shared B. Al-Zaid· 1 shared B. Kellam· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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3 shared papersPharmacology & Toxicology

C. W. White

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Single-molecule analysis of receptor-beta-arrestin interactions in living cells

J. Grimes, Z. Koszegi, Y. Lanoiselee, T. Miljus, S. L. O'Brien, T. M. Stepniewski, B. Medel-Lacruz, M. Baidya, M. Makarova, D. M. Owen, A. K. Shukla, J. Selent, S. J. Hill, D. Calebiro

This study uses single-molecule microscopy and simulations to show that beta-arrestin inserts into the lipid bilayer and interacts with receptors through lateral diffusion, challenging existing models of its function.

bioRxiv · Nov 15, 2022 · PreprintCell Biology

CXCL17 is an endogenous inhibitor of CXCR4 via a novel mechanism of action

C. W. White, L. E. Kilpatrick, N. Dale, R. S. Abhayawardana, S. Dekkers, M. J. Stocks, K. D. Pfleger, S. J. Hill

This study identifies CXCL17 as an endogenous inhibitor of CXCR4 through a novel mechanism involving interaction with neuropillin-1 and glycosaminoglycan binders.

bioRxiv · Jul 5, 2021 · PreprintPharmacology & Toxicology

RAMPs regulate signalling bias and internalisation of the GIPR

M. Harris, D. I. Mackie, J. B. Pawlak, S. Carvalho, T. T. truong, D. Safitri, H. Y. Yeung, S. Routledge, M. T. Harper, B. Al-Zaid, M. Soave, S. Al-Sabah, A. Inoue, D. R. Poyner, S. J. Hill, , G. Ladds

This study shows RAMPs modulate GIPR signaling and internalization, with RAMP3 reducing cAMP production and promoting surface retention, while RAMP1/2 decrease Gq/11/15 activation, and RAMP1 is essential for normal glucose regulation.

bioRxiv · Apr 8, 2021 · PreprintPharmacology & Toxicology

A Nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding.

C. W. White, K. D. Pfleger, S. J. Hill

This paper develops a Nanoluciferase biosensor to quantify and monitor chemokine secretion and receptor binding in live cells.

bioRxiv · Aug 19, 2020Pharmacology & Toxicology

Ligand-directed covalent labelling of a GPCR with a fluorescent tag

L. A. Stoddart, N. D. Kindon, O. Otun, C. R. Harwood, F. Patera, D. B. Veprintsev, J. Woolard, S. J. Briddon, H. A. Franks, S. J. Hill, B. Kellam

The paper describes a compound that covalently labels a GPCR with a fluorescent tag without blocking its binding site, enabling study of native GPCR function and localization.

bioRxiv · Apr 21, 2020Pharmacology & Toxicology

Optimised CRISPR-Cas9 mediated single molecule imaging for accurate quantification through endogenous expression.

A. O. Khan, C. W. White, J. A. Pike, J. Yule, A. Slater, S. J. Hill, N. S. Poulter, S. G. Thomas, N. V. Morgan

This study optimizes CRISPR-Cas9 for single molecule imaging by improving mEos variants and shows endogenous labeling enables accurate quantification of CXCR4.

bioRxiv · Nov 30, 2018 · PreprintCell Biology