J. A. Pike

A new paradigm of intracrine free fatty acid receptor 4 signaling at lipid droplets

The paper shows FFA4, a GPCR, signals from lipid droplet-associated membranes in adipocytes, providing localized feedback to regulate lipolysis.

A framework for evaluating the performance of SMLM cluster analysis algorithms

The paper evaluates SMLM cluster analysis algorithms using ARI and IoU metrics across simulated scenarios to establish a standard framework for future algorithm development.

Post-translational polymodification of β1 tubulin regulates motor protein localisation in platelet production and function

The paper investigates how post-translational polymodifications of β1 tubulin regulate motor protein localization in platelet production and function using patient data, iPSC-derived megakaryocytes, and platelets.

Immobilised collagen prevents shedding and induces sustained GPVI clustering and signalling in platelets.

This study shows immobilized collagen prevents GPVI shedding and sustains its clustering and signaling in platelets for at least 3 hours.

Optimised CRISPR-Cas9 mediated single molecule imaging for accurate quantification through endogenous expression.

This study optimizes CRISPR-Cas9 for single molecule imaging by improving mEos variants and shows endogenous labeling enables accurate quantification of CXCR4.