Author

A. P. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:human· 5 Research Focus:drug response / drug discovery· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1

Frequent Co-Authors

Y.-H. Chen· 4 shared R. Jiang· 3 shared C. C. Hughes· 2 shared A. Agrawal· 1 shared A. Tankazyan· 1 shared B. Cardenas-Benitez· 1 shared C. J. Hatch· 1 shared D. A. Lawson· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersBioengineering

Y.-H. Chen

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular Lesions

J. Fang, C. J. Hatch, J. Andrejecsk, W. Van Trigt, D. J. Juat, Y.-H. Chen, S. Matsumoto, A. P. Lee, C. C. Hughes

This paper develops a microphysiological HHT-on-a-chip platform that recapitulates patient vascular lesions and demonstrates sensitivity to pazopanib, a drug effective in HHT patients.

bioRxiv · Mar 11, 2024 · PreprintCell Biology

Three-dimensional Isotropic Imaging of Live Suspension Cells Enabled by Droplet Microvortices

B. Cardenas-Benitez, R. Hurtado, X. Luo, A. P. Lee

This paper introduces ADOPT, a method for 3D isotropic imaging of live suspension cells using microfluidic droplets and OPT, revealing distinct nuclear content distributions in immune cells.

bioRxiv · Dec 1, 2023Biophysics

Titering of Chimeric Antigen Receptors on CAR T Cells enabled by a Microfluidic-based Dosage-Controlled Intracellular mRNA Delivery Platform

Y.-H. Chen, R. Jiang, A. P. Lee

This paper introduces a microfluidic platform for controlled delivery of CAR gene mRNA to T cells, enabling titering of CAR expression on their surface.

bioRxiv · Mar 14, 2023 · PreprintBioengineering

3D Confinement-enabled Priming of Synaptic Activation Promotes Primary T Cell Expansion

R. Jiang, Y.-H. Chen, R. Parajuli, A. Agrawal, A. P. Lee

This paper introduces a 3D confinement method to prime T cell-MHC immune synapses, achieving faster T cell expansion compared to conventional methods.

bioRxiv · Mar 2, 2023 · PreprintImmunology

High-throughput and dosage-controlled intracellular delivery of large cargos by an acoustic-electric micro-vortices platform

M. Aghaamoo, Y.-H. Chen, X. Li, N. Garg, R. Jiang, A. P. Lee

The paper introduces a microfluidic platform for high-throughput, dosage-controlled intracellular delivery of large cargos with high viability and efficiency.

bioRxiv · Feb 16, 2021Bioengineering

An In Vitro Vascularized Micro-Tumor Model of Human Colorectal Cancer Recapitulates In Vivo Drug Responses

S. J. Hachey, S. Movsesyan, Q. H. Nguyen, G. Burton-Sojo, A. Tankazyan, J. Wu, T. Hoang, M. M. Hatch, D. Zhao, E. Celaya, S. Gomez, G. T. Chen, R. T. Davis, K. Nee, N. Pervolarakis, , C. C. Hughes

This paper validates a vascularized micro-tumor model for colorectal cancer that better replicates in vivo drug responses than traditional 2D or 3D models.

bioRxiv · Mar 3, 2020Cancer Biology