Author

C. J. Hatch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 2 Assay:scRNA-seq· 2 Research Focus:differential expression· 1

Frequent Co-Authors

C. C. Hughes· 3 shared S. J. Hachey· 2 shared A. Mocherla· 1 shared A. P. Lee· 1 shared D. Gaebler· 1 shared D. J. Juat· 1 shared H. Zhu· 1 shared J. Andrejecsk· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

C. C. Hughes

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Author profile →

3 papers

Recent·Most cited

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular Lesions

J. Fang, C. J. Hatch, J. Andrejecsk, W. Van Trigt, D. J. Juat, Y.-H. Chen, S. Matsumoto, A. P. Lee, C. C. Hughes

This paper develops a microphysiological HHT-on-a-chip platform that recapitulates patient vascular lesions and demonstrates sensitivity to pazopanib, a drug effective in HHT patients.

bioRxiv · Mar 11, 2024 · PreprintCell Biology

Targeting tumor-stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model

S. J. Hachey, C. J. Hatch, D. Gaebler, A. Mocherla, K. Nee, K. Kessenbrock, C. C. Hughes

The paper uses a vascularized micro-tumor model to identify therapeutic targets in TNBC stromal interactions, showing efficacy of Tie2 and Her3/Akt inhibition.

bioRxiv · Sep 6, 2023Cancer Biology

Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

K. V. Nguyen Ngoc, S. Sai, Y. Jun, R. H. F. Bender, V. Kravets, H. Zhu, C. J. Hatch, M. Schlichting, R. Gaetani, M. Mallick, S. J. Hachey, K. Christman, S. C. George, C. C. Hughes, M. Sander

This study shows that engineered vasculature enhances the function of stem cell-derived islet organoids by improving calcium influx and insulin secretion in beta-cells.

bioRxiv · Oct 28, 2022 · PreprintCell Biology