S. Matsumoto

Molecular dynamics unveils multiple-site binding of inhibitors with reduced activity on the surface of dihydrofolate reductase

This study uses molecular dynamics to analyze inhibitor binding to DHFR, showing that reduced activity correlates with multiple-bound states on the protein surface.

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular Lesions

This paper develops a microphysiological HHT-on-a-chip platform that recapitulates patient vascular lesions and demonstrates sensitivity to pazopanib, a drug effective in HHT patients.

Highly efficient transgenic mouse production using piggyBac and its application to rapid phenotyping at the founder generation

This study improves transgenic mouse production efficiency using piggyBac, enabling phenotyping in the founder generation and demonstrating application with bacterial artificial chromosome transgenes.

Mimicking seasonal changes in light-dark cycle and ambient temperature modulates gut microbiome in mice under the same dietary regimen

This study shows that altering light-dark cycles and temperature in mice changes their gut microbiome composition, mimicking seasonal effects without changing diet.

Genome-wide analysis of R2R3-MYB transcription factors in Japanese morning glory

This study identifies and classifies 126 R2R3-MYB genes in Japanese morning glory, linking their functions to Arabidopsis orthologs and suggesting roles in cell division, anthocyanin biosynthesis, and stress response.

Pelagic seabirds reduce risk by flying into the eye of the storm

The paper tracks seabirds during cyclones and finds they fly toward the storm's eye in strong winds to avoid onshore winds, revealing navigational strategies and risks for juveniles.

Intracellular force comparison of pathogenic KIF1A, KIF5, and dynein by fluctuation analysis

The paper compares intracellular force and velocity of KIF1A, KIF5, and dynein using fluctuation analysis and finds impaired force and velocity in specific KIF1A variants.

SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator

The paper identifies TSPAN8 as a novel mediator of SARS-CoV-2 infection in lung organoids, showing its correlation with infection rates and susceptibility to blocking antibodies.

Recruitment of KRAS downstream target ARL4C to membrane protrusions accelerates pancreatic cancer cell invasion.

This study identifies ARL4C's role in pancreatic cancer invasion by localizing it to membrane protrusions and showing its interaction with IQGAP1 and MMP14, leading to extracellular matrix degradation and metastasis suppression via ASO.

Exploring ligand binding pathways on proteins using hypersound-accelerated molecular dynamics

This study accelerates molecular dynamics simulations using ultrasound to study ligand binding pathways on proteins, revealing previously undetectable kinetic features and binding pathways.

AI on animals: AI-assisted animal-borne logger never misses the moments that biologists want

This paper introduces AI-assisted biologgers that use intelligent sensor control to focus data collection on specific target behaviors, improving resource efficiency during long deployments.

Distinguishing Closely Related Pancreatic Cancer Subtypes In Vivo by 13C Glucose MRI without Hyperpolarization

The paper distinguishes closely related pancreatic cancer subtypes in vivo using 13C glucose MRI without hyperpolarization by detecting metabolic differences through tensor decomposition.