Author

C. C. Hughes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 5 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 2 Assay:organoid / primary culture· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

S. J. Hachey· 4 shared C. J. Hatch· 3 shared A. P. Lee· 2 shared D. J. Juat· 2 shared K. Kessenbrock· 2 shared K. Nee· 2 shared M. Sander· 2 shared R. Gaetani· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersCancer Biology

S. J. Hachey

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

CDC42 Inhibitors Alter Patterns of Vessel Arborization in Skin and Tumors in vivo

L. M. Vuong, S. J. Hachey, J. Shiu, D. F. Xie, N. Salvador, N. Brindani, S. M. Bertozzi, M. Summa, R. Bertorelli, A. Armirotti, R. Pham, V. S. Ku, T. Nguyen, B. Choi, C. C. Hughes, , A. K. Ganesan

This study identifies CDC42 inhibitors that reduce vessel branching in both normal skin and tumors, offering potential for treating skin cancer and angiogenesis-related diseases.

bioRxiv · Apr 9, 2024 · PreprintCancer Biology

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular Lesions

J. Fang, C. J. Hatch, J. Andrejecsk, W. Van Trigt, D. J. Juat, Y.-H. Chen, S. Matsumoto, A. P. Lee, C. C. Hughes

This paper develops a microphysiological HHT-on-a-chip platform that recapitulates patient vascular lesions and demonstrates sensitivity to pazopanib, a drug effective in HHT patients.

bioRxiv · Mar 11, 2024 · PreprintCell Biology

Targeting tumor-stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model

S. J. Hachey, C. J. Hatch, D. Gaebler, A. Mocherla, K. Nee, K. Kessenbrock, C. C. Hughes

The paper uses a vascularized micro-tumor model to identify therapeutic targets in TNBC stromal interactions, showing efficacy of Tie2 and Her3/Akt inhibition.

bioRxiv · Sep 6, 2023Cancer Biology

Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

K. V. Nguyen Ngoc, S. Sai, Y. Jun, R. H. F. Bender, V. Kravets, H. Zhu, C. J. Hatch, M. Schlichting, R. Gaetani, M. Mallick, S. J. Hachey, K. Christman, S. C. George, C. C. Hughes, M. Sander

This study shows that engineered vasculature enhances the function of stem cell-derived islet organoids by improving calcium influx and insulin secretion in beta-cells.

bioRxiv · Oct 28, 2022 · PreprintCell Biology

A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction

R. H. F. Bender, B. T. O'Donnell, B. Shergill, B. Q. Pham, D. J. Juat, M. S. Hatch, V. S. Shirure, M. Wortham, K.-V. Nguyen-Ngoc, Y. Jun, R. Gaetani, K. L. Christman, L. Teyton, S. C. George, M. Sander, C. C. Hughes

This paper develops a vascularized 3D model of human pancreatic islets to study immune cell interactions and islet destruction in diabetes.

bioRxiv · Dec 21, 2021Cell Biology

An In Vitro Vascularized Micro-Tumor Model of Human Colorectal Cancer Recapitulates In Vivo Drug Responses

S. J. Hachey, S. Movsesyan, Q. H. Nguyen, G. Burton-Sojo, A. Tankazyan, J. Wu, T. Hoang, M. M. Hatch, D. Zhao, E. Celaya, S. Gomez, G. T. Chen, R. T. Davis, K. Nee, N. Pervolarakis, , C. C. Hughes

This paper validates a vascularized micro-tumor model for colorectal cancer that better replicates in vivo drug responses than traditional 2D or 3D models.

bioRxiv · Mar 3, 2020Cancer Biology