Author

A. Proudfoot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

A. Frank· 1 shared A. Hyrina· 1 shared C. C. Ward· 1 shared D. Bussiere· 1 shared D. E. Bussiere· 1 shared D. K. Nomura· 1 shared E. Ornleas· 1 shared J. A. Olzmann· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiophysics

A. Frank

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Author profile →

2 papers

Recent·Most cited

Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation

J. N. Spradlin, X. Hu, C. C. Ward, S. M. Brittain, M. D. Jones, L. Ou, M. To, A. Proudfoot, E. Ornleas, M. Woldegiorgis, J. A. Olzmann, D. E. Bussiere, J. R. Thomas, J. A. Tallarico, J. M. McKenna, , D. K. Nomura

This study identifies nimbolide's mechanism of action by showing it targets RNF114, leading to stabilization of p21 and inhibition of breast cancer cell proliferation.

bioRxiv · Apr 9, 2019Cancer Biology

First Crystal Structure of a Non-Structural Hepatitis E Viral Protein Identifies a Putative Novel Zinc-Binding Protein

A. Proudfoot, A. Hyrina, M. Holdorf, A. Frank, D. Bussiere

The paper determines the crystal structure of a non-structural HEV protein, revealing a zinc-binding motif and structural homology to a fatty acid binding domain.

bioRxiv · Feb 2, 2019Biophysics