Author

L. Ou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

B. Zhang· 2 shared C. Cheng· 2 shared J. Gorman· 2 shared T. Zhou· 2 shared X. Zhao· 2 shared Y. Tsybovsky· 2 shared Y. Yang· 2 shared A. Biju· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersImmunology

B. Zhang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular mechanism of NAD+ binding to the Nudix homology domains of DBC1

L. Ou, X. Zhao, I. Wu, Z. Xiong, Z. Ruan, G. Zhou, W. Chen

This study investigates how NAD+ binds to DBC1's Nudix homology domains using NMR, ITC, and molecular docking, revealing key residues and binding affinity.

bioRxiv · Oct 27, 2023 · PreprintBiochemistry

Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of Vulnerability

J. Gorman, C. S.-F. Cheung, Z. Duan, Y. Sun, P. Wang, J. C. Boyington, A. Biju, T. Bylund, C. Cheng, L. Ou, T. Stephens, Y. Tsybovsky, R. Verardi, S. Wang, Y. Yang, , P. D. Kwong

This paper develops a prefusion-stabilized Lassa virus GPC, identifies a neutralizing nanobody, and reveals a cleavage-dependent site of vulnerability at the trimer apex.

bioRxiv · Apr 21, 2022 · PreprintImmunology

Gut microbiome couples gut and brain during calorie restriction in treating obesity

Q. Zeng, Q. Wang, T. Xiang, L. Ou, X. Wu, K. Cai, C. Geng, M. Han, Z. Li, Z. Li, W. Wang, T. Yang, F. Li, H. Ma, X. Zhao, , J. Wang

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

bioRxiv · Dec 4, 2020 · PreprintMicrobiology

Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation

J. N. Spradlin, X. Hu, C. C. Ward, S. M. Brittain, M. D. Jones, L. Ou, M. To, A. Proudfoot, E. Ornleas, M. Woldegiorgis, J. A. Olzmann, D. E. Bussiere, J. R. Thomas, J. A. Tallarico, J. M. McKenna, , D. K. Nomura

This study identifies nimbolide's mechanism of action by showing it targets RNF114, leading to stabilization of p21 and inhibition of breast cancer cell proliferation.

bioRxiv · Apr 9, 2019Cancer Biology

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

K. Xu, P. Acharya, R. Kong, C. Cheng, G.-Y. Chuang, K. Liu, M. K. Louder, S. O Dell, R. Rawi, M. Sastry, C.-H. Shen, B. Zhang, T. Zhou, M. Asokan, R. T. Bailer, , McDermott

This study shows that targeting the HIV-1 fusion peptide with specific immunogens induces cross-clade neutralizing antibodies in animals.

bioRxiv · Apr 23, 2018Immunology