Author

A. R. Paredez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Assay:imaging· 2 Organism:mouse· 2

Frequent Co-Authors

G. C. M. Alas· 3 shared E. A. Merritt· 2 shared E. B. Thomas· 2 shared H.-W. Shih· 2 shared J. Krtkova· 2 shared M. C. Steele-Ogus· 2 shared M. J. MacCoss· 2 shared M. Steele-Ogus· 2 shared

Activity by Year

2017-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

G. C. M. Alas

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Disc and Actin-Associated Protein 1 Influence Attachment in the Intestinal Parasite Giardia lamblia

M. C. Steele-Ogus, A. M. Obenaus, N. J. Sniadecki, A. R. Paredez

This study investigates the role of GlActin and DAAP1 in Giardia lamblia's ventral disc function and attachment, finding that DAAP1 depletion impairs attachment despite intact discs.

bioRxiv · Aug 6, 2021Cell Biology

Identification of Actin Filament Interactors in Giardia lamblia

M. C. Steele-Ogus, R. Johnson, M. J. MacCoss, A. R. Paredez

This study identifies 46 putative actin filament interactors in Giardia lamblia, including proteins localized to the ventral disc, suggesting a role for GlActin in host attachment.

bioRxiv · May 19, 2021Microbiology

Stage-specific, morphological and molecular markers of encystation in Giardia lamblia

E. B. Thomas, R. Sutanto, R. S. Johnson, H.-W. Shih, J. Krtkova, M. J. MacCoss, A. R. Paredez

This paper introduces a staging system for Giardia encystation based on ESV morphology and molecular markers, validated through GlRac and Rab GTPase analysis.

bioRxiv · Feb 1, 2021Cell Biology

The Giardia lamellipodium-like ventrolateral flange supports attachment and rapid cytokinesis

W. R. Hardin, G. C. M. Alas, N. Taparia, E. B. Thomas, M. Steele-Ogus, K. L. Hvorecny, A. R. Halpern, P. Tumova, J. M. Kollman, J. C. Vaughan, N. J. Sniadecki, A. R. Paredez

This paper identifies Flangin, an actin-associated protein essential for forming the ventrolateral flange (VLF) in Giardia, which supports attachment and rapid cytokinesis.

bioRxiv · Jan 31, 2021Cell Biology

Nek8445, a protein kinase required for microtubule regulation and cytokinesis in Giardia lamblia

K. M. Hennessey, G. C. M. Alas, I. Rogiers, R. Li, E. A. Merritt, A. R. Paredez

This study identifies Nek8445's role in microtubule regulation and cytokinesis in Giardia lamblia, showing its impact on cell shape and axoneme exit.

bioRxiv · May 20, 2020Cell Biology

Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model

S. A. Michaels, H.-W. Shih, B. Zhang, E. D. Navaluna, Z. Zhang, R. M. Ranade, J. R. Gillespie, E. A. Merritt, E. Fan, F. S. Buckner, A. R. Paredez, K. K. Ojo

The paper develops a luciferase-based murine model and cell assay to evaluate the efficacy of MetRS inhibitor 1717 against Giardia lamblia, showing its potent in vivo activity.

bioRxiv · Oct 29, 2019Microbiology

14-3-3 Negatively Regulates Actin Filament Formation In The Deep Branching Eukaryote Giardia lamblia

J. Krtkova, J. Xu, M. Lalle, M. Steele-Ogus, G. C. M. Alas, D. Sept, A. R. Paredez

This study shows that 14-3-3 negatively regulates actin filament formation in Giardia lamblia by interacting with actin and modulating its phosphorylation state.

bioRxiv · May 26, 2017Cell Biology