Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate wide-spread non-receptor mediated immune cell recruitment
A. L. Gray, R. Karlsson, A. R. Roberts, A. J. Ridley, N. Pun, C. Hughes, L. Medina-Ruiz, H. Birchenough, C. Salanga, E. A. Yates, J. E. Turnbull, T. M. Handel, G. Graham, T. A. Jowitt, I. Schiessl, , D. P. Dyer
The paper shows CXCL4 binds to extracellular matrix proteoglycans, increasing vascular permeability and recruiting various leukocytes through a non-canonical mechanism.
bioRxiv · Jul 10, 2022 · PreprintImmunology