Author

R. Karlsson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

R. L. Miller· 3 shared A. J. Ridley· 2 shared D. Jaen-Luchoro· 2 shared D. P. Dyer· 2 shared E. A. Yates· 2 shared E. R. B. Moore· 2 shared F. Salva-Serra· 2 shared J. E. Turnbull· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

R. L. Miller

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Responses of carbapenemase-producing and non-producing carbapenem-resistant Pseudomonas aeruginosa strains to meropenem revealed by quantitative tandem mass spectrometry proteomics

F. Salva-Serra, D. Jaen-Luchoro, N. P. Marathe, I. Adlerberth, E. R. B. Moore, R. Karlsson

This study uses proteomics to compare the responses of carbapenem-resistant Pseudomonas aeruginosa strains with different resistance mechanisms to sub-MICs of meropenem, identifying differentially expressed proteins and pathways.

bioRxiv · Oct 23, 2022Microbiology

Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans

A. J. Ridley, Y. Ou, R. Karlsson, N. Pun, H. L. Birchenough, T. A. Jowitt, C. Lawless, R. L. Miller, D. P. Dyer

The paper analyzes chemokine gene expression across species, tissues, and diseases, showing complex patterns and demonstrates that ECM proteoglycans modulate chemokine signaling and leukocyte recruitment.

bioRxiv · Sep 20, 2022Immunology

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate wide-spread non-receptor mediated immune cell recruitment

A. L. Gray, R. Karlsson, A. R. Roberts, A. J. Ridley, N. Pun, C. Hughes, L. Medina-Ruiz, H. Birchenough, C. Salanga, E. A. Yates, J. E. Turnbull, T. M. Handel, G. Graham, T. A. Jowitt, I. Schiessl, , D. P. Dyer

The paper shows CXCL4 binds to extracellular matrix proteoglycans, increasing vascular permeability and recruiting various leukocytes through a non-canonical mechanism.

bioRxiv · Jul 10, 2022 · PreprintImmunology

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction

S. E. Guimond, C. J. Mycroft-West, N. S. Gandhi, J. A. Tree, T. T. Le, C. M. Spalluto, M. V. Humbert, K. R. Buttigieg, N. Coombes, M. J. Elmore, K. Nystrom, J. Said, Y. X. Setoh, A. Amarilla, N. Modhiran, , J. E. Turnbull

This paper shows that pixatimod inhibits SARS-CoV-2 by disrupting the Spike-ACE2 interaction, demonstrating its potential as an anti-COVID-19 therapeutic.

bioRxiv · Jun 24, 2020Microbiology

First complete genome sequences of Streptococcus pyogenes NCTC 8198T and CCUG 4207T, the type strain of the type species of the genus Streptococcus: 100% match in length and sequence identity between PacBio solo and Illumina plus Oxford Nanopore hybrid assemblies

F. Salva-Serra, D. Jaen-Luchoro, H. E. Jakobsson, L. Gonzales-Siles, R. Karlsson, A. Busquets, M. Gomila, A. Bennasar-Figueras, J. E. Russell, M. Abbas Fazal, S. Alexander, E. R. B. Moore

bioRxiv · Mar 10, 2020Microbiology