Author

C. Hughes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Bioengineering· 1 Biophysics· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:imaging· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

D. P. Dyer· 2 shared L. Medina-Ruiz· 2 shared A. Borensztejn· 1 shared A. Bruneau· 1 shared A. F. Stewart· 1 shared A. Haupt· 1 shared A. J. Ridley· 1 shared A. L. Gray· 1 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersImmunology

D. P. Dyer

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate wide-spread non-receptor mediated immune cell recruitment

A. L. Gray, R. Karlsson, A. R. Roberts, A. J. Ridley, N. Pun, C. Hughes, L. Medina-Ruiz, H. Birchenough, C. Salanga, E. A. Yates, J. E. Turnbull, T. M. Handel, G. Graham, T. A. Jowitt, I. Schiessl, , D. P. Dyer

The paper shows CXCL4 binds to extracellular matrix proteoglycans, increasing vascular permeability and recruiting various leukocytes through a non-canonical mechanism.

bioRxiv · Jul 10, 2022 · PreprintImmunology

Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice

L. Medina-Ruiz, R. Bartolini, D. P. Dyer, F. Vidler, C. Hughes, F. Schuette, S. Love, J. Fu, A. F. Stewart, G. J. Graham

This study generates multi-chemokine receptor reporter mice to analyze receptor expression dynamics on myeloid cells, revealing high specificity and selectivity in chemokine receptor expression.

bioRxiv · Aug 11, 2021Immunology

An Investigation into Patient-Specific 3D Printed Titanium Stents and the use of Etching to Overcome Selective Laser Melting Design Constraints.

O. M. McGee, S. Geraghty, C. Hughes, P. Jamshidi, D. P. Kenny, M. M. Attallah, C. M. Lally

This paper investigates using etching to improve 3D printed titanium stents for pediatric patients, enhancing design flexibility and surface finish through computational and experimental methods.

bioRxiv · Mar 7, 2021Bioengineering

Recognition of discrete export signals in flagellar subunits during bacterial Type III secretion

O. J. Bryant, P. Dhillon, C. Hughes, G. M. Fraser

The paper identifies a second export signal in bacterial flagellar subunits and shows its hydrophobicity is key to export, with implications for export gate opening.

bioRxiv · Dec 9, 2020Microbiology

Robust integrated intracellular organization of the human iPS cell: where, how much, and how variable

M. P. Viana, J. Chen, T. A. Knijnenburg, R. Vasan, C. Yan, J. E. Arakaki, M. Bailey, B. Berry, A. Borensztejn, J. M. Brown, S. Carlson, J. A. Cass, B. Chaudhuri, K. R. Cordes Metzler, M. E. Coston, , Leung

The paper establishes quantitative rules for the locations, amounts, and variation of 25 cellular structures in human iPSCs using high-resolution imaging and analysis.

bioRxiv · Dec 8, 2020 · PreprintCell Biology

Single-molecule light-sheet microscopy with local nanopipette delivery

B. Li, A. Ponjavic, W.-H. Chen, L. Hopkins, C. Hughes, Y. Ye, C. E. Bryant, D. Klenerman

This paper introduces ldSPIM, a method combining light sheet microscopy with nanopipette delivery to precisely deliver single molecules to cells and image their effects in real-time.

bioRxiv · Sep 25, 2020Biophysics

Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival

N. Baker, C. M. C. Catta-Preta, R. Neish, J. Sadlova, B. Powell, E. V. C. Alves-Ferreira, V. Geohegan, J. B. T. Carnielli, K. Newling, C. Hughes, B. Vojtkova, J. Anand, A. Mihut, P. Walrad, L. G. Wilson, , J. C. Mottram

The paper systematically analyzes Leishmania protein kinases to identify those regulating differentiation and survival across life cycle stages.

bioRxiv · Sep 6, 2020Microbiology

The Origin and Early Evolution of the Legumes are a Complex Paleopolyploid Phylogenomic Tangle closely associated with the Cretaceous-Paleogene (K-Pg) Boundary

E. Koenen, D. Ojeda, R. Steeves, J. Migliore, F. Bakker, J. Wieringa, C. Kidner, O. Hardy, T. Pennington, P. Herendeen, A. Bruneau, C. Hughes

This study investigates the origin and early evolution of legumes, finding multiple whole genome duplication events linked to the K-Pg boundary mass extinction and suggesting a complex polyploid history.

bioRxiv · Mar 16, 2019Evolutionary Biology