Author

T. A. Jowitt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. J. Ridley· 2 shared C. Baldock· 2 shared D. P. Dyer· 2 shared N. Pun· 2 shared R. Karlsson· 2 shared R. L. Miller· 2 shared A. Gerken· 1 shared A. J. Day· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

A. J. Ridley

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans

A. J. Ridley, Y. Ou, R. Karlsson, N. Pun, H. L. Birchenough, T. A. Jowitt, C. Lawless, R. L. Miller, D. P. Dyer

The paper analyzes chemokine gene expression across species, tissues, and diseases, showing complex patterns and demonstrates that ECM proteoglycans modulate chemokine signaling and leukocyte recruitment.

bioRxiv · Sep 20, 2022Immunology

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate wide-spread non-receptor mediated immune cell recruitment

A. L. Gray, R. Karlsson, A. R. Roberts, A. J. Ridley, N. Pun, C. Hughes, L. Medina-Ruiz, H. Birchenough, C. Salanga, E. A. Yates, J. E. Turnbull, T. M. Handel, G. Graham, T. A. Jowitt, I. Schiessl, , D. P. Dyer

The paper shows CXCL4 binds to extracellular matrix proteoglycans, increasing vascular permeability and recruiting various leukocytes through a non-canonical mechanism.

bioRxiv · Jul 10, 2022 · PreprintImmunology

Transglutaminase mediated asprosin oligomerization allows its tissue storage as fibers

Y. A. Morcos, G. Pryymachuk, S. Luetke, A. Gerken, A. R. Godwin, T. A. Jowitt, N. Piekarek, T. Hoffmann, A. Niehoff, M. Odenthal, U. Drebber, O. Grisk, Y. Ladilov, W. Bloch, B. Callewaert, , G. Sengle

The paper identifies transglutaminase-mediated asprosin oligomerization and extracellular fiber formation in connective tissues, suggesting a new mechanism for tissue storage and regulation of asprosin bioavailability.

bioRxiv · Jan 4, 2022 · PreprintBiochemistry

Heavy chain-1 of inter-α-inhibitor has an integrin-like structure with immune regulatory activities

D. J. Briggs, A. W. W. Langford-Smith, T. A. Jowitt, C. M. Kielty, J. J. Enghild, C. Baldock, C. M. Milner, A. J. Day

This paper identifies HC1 of inter-α-inhibitor as having an integrin-like structure with immune regulatory functions through inhibition of the alternative pathway C3 convertase.

bioRxiv · Jul 8, 2019 · PreprintBiochemistry