D. Ferguson

Co-dependent formation of the Toxoplasma gondii subpellicular microtubules and inner membrane skeleton

This study investigates the formation of subpellicular microtubules in Toxoplasma gondii using expansion microscopy and genetic analysis, revealing their co-dependent assembly with the inner membrane skeleton.

Evaluation of the cross reactivity of neutralising antibody response in vaccinated human and convalescent hamster sera against SARS-CoV-2 variants up to and including JN.1 using an authentic virus neutralisation assay

This study evaluates neutralising antibody responses in vaccinated humans and convalescent hamsters against SARS-CoV-2 variants up to JN.1 using an authentic virus neutralisation assay, finding increased resistance to JN.1 in vaccinated individuals and specific neutralisation patterns in hamsters.

Disruption of Hepatic Mitochondrial Pyruvate and Amino Acid Metabolism Impairs Gluconeogenesis and Endurance Exercise Capacity in Mice

Atypical flagella assembly and haploid genome coiling during male gamete formation in Plasmodium

This study uses electron microscopy to reveal the 3D organization of axonemes and genome coiling during male gamete formation in Plasmodium berghei.

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and glycerol-mediated gluconeogenesis in mice

This study investigates how liver mitochondrial pyruvate carrier deficiency affects de novo lipogenesis and glycerol-mediated gluconeogenesis in mice, finding impaired DNL but no reduction in intrahepatic lipid and unchanged glucose levels despite reduced glycerol metabolism.

Mitochondrial Pyruvate Carrier Inhibition Attenuates Hepatic Stellate Cell Activation and Liver Injury in a Mouse Model of Metabolic Dysfunction-associated Steatotic Liver Disease

Adipocyte lipin 1 is positively associated with metabolic health in humans and regulates systemic metabolism in mice.

The paper shows that lower adipose lipin 1 in humans correlates with metabolic issues, and mice lacking adipocyte lipin 1 develop metabolic disorders.

Mitochondrial Pyruvate Carrier Inhibition Initiates Metabolic Crosstalk to Stimulate Branched Chain Amino Acid Catabolism

This study shows that inhibiting the mitochondrial pyruvate carrier reduces branched chain amino acid (BCAA) levels and phosphorylation of BCKDH by activating AMPK/mTOR signaling in patients with NASH and in vitro models.

Plasmodium SAS4/CPAP is a flagellum basal body component during male gametogenesis but is not essential for parasite transmission

This study investigates the role of SAS4/CPAP in Plasmodium male gametogenesis, showing it is part of the basal body but not essential for gamete formation or parasite transmission.

SARS-CoV-2 Virus like Particles produced by a single recombinant baculovirus generate potent neutralizing antibody that protects against variant challenge

This study generates SARS-CoV-2 virus-like particles using baculovirus expression, showing they induce neutralizing antibodies and protect against variant challenge in a hamster model.

Gut Microbe-Targeted Choline Trimethylamine Lyase Inhibition Improves Obesity Via Rewiring of Host Circadian Rhythms

The paper shows that inhibiting gut microbial choline TMA-lyase reduces obesity in mice by altering microbiome composition and host circadian rhythms.

MRE11 is crucial for malaria transmission and its absence affects expression of interconnected networks of key genes essential for life

This study shows that MRE11 is essential for Plasmodium development in mosquitoes, with its absence causing transcriptional changes in critical biological processes and blocking parasite transmission.

Plasmodium DEH is ER-localized and crucial for oocyst mitotic division during malaria transmission

This study identifies DEH as an ER-localized protein essential for oocyst mitotic division in Plasmodium berghei, disrupting sporogony and parasite transmission.

A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of Plasmodium berghei during gametogony and parasite transmission.

This study identifies CRK5 as a critical regulator of atypical DNA replication in Plasmodium berghei during gametogony and mosquito transmission.

Adipose Tissue is a Critical Regulator of Osteoarthritis

This study shows adipose tissue, not body weight, drives osteoarthritis progression through paracrine signaling in a mouse model of lipodystrophy.

Human bone marrow disorders recapitulated in vitro using organ chip technology

The paper describes a Bone Marrow-on-a-Chip model that mimics bone marrow function and disease states, including drug and radiation responses and Shwachman-Diamond Syndrome abnormalities.