Modified defence peptides from horseshoe crab target and kill bacteria inside host cells
A. S. Amiss, J. B. von Pein, J. R. Webb, N. D. Condon, P. J. Harvey, M.-D. Phan, M. A. Schembri, B. J. Currie, M. J. Sweet, D. J. Craik, R. Kapetanovic, S. T. Henriques, N. Lawrence
This study identifies modified antimicrobial peptides from horseshoe crabs that effectively kill bacteria, including UPEC, both extracellularly and intracellularly, with reduced toxicity to mammalian cells.
bioRxiv · Jun 27, 2021Microbiology