M. Mayo

Evolving a High-Performance Terminal Deoxynucleotidyl Transferase for Enzymatic DNA Synthesis

This paper evolves a terminal deoxynucleotidyl transferase for enzymatic DNA synthesis using modified substrates, showing improved activity, template promiscuity, and thermostability.

Population sequencing for diversity and transmission analyses

This paper introduces and validates population sequencing methods to analyze phylogenetic diversity in bacterial populations without haplotype reconstruction, demonstrating applications in tracking transmission and understanding pathogen dynamics.

Drug susceptibility profiling of Australian Burkholderia species as models for developing melioidosis therapeutics

The paper profiles drug susceptibility of Australian Burkholderia species to identify models for developing melioidosis therapeutics, finding high similarity in susceptibility profiles between B. pseudomallei and less pathogenic species.

Comparative genomics confirms a rare melioidosis human-to-human transmission event and reveals incorrect phylogenomic reconstruction due to polyclonality

This paper investigates a rare human-to-human transmission of Burkholderia pseudomallei from mother to child using whole-genome sequencing, revealing polyclonality in the mother and demonstrating how mixture can mislead phylogenomic analysis.

Pathogen to commensal: longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection

This study tracks the long-term evolution of Burkholderia pseudomallei in a human host over 16 years, showing its transition from a pathogen to a commensal through genetic and phenotypic changes.

Raising the stakes: Loss of efflux-pump regulation decreases meropenem susceptibility in Burkholderia pseudomallei

This study identifies mutations in RND efflux pump regulators in B. pseudomallei isolates that lead to decreased meropenem susceptibility and are associated with fatal melioidosis outcomes.