B. J. Currie

Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

The paper shows extensive genomic overlap between Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis, including shared genes and recombination events, with implications for vaccine development.

Modified defence peptides from horseshoe crab target and kill bacteria inside host cells

This study identifies modified antimicrobial peptides from horseshoe crabs that effectively kill bacteria, including UPEC, both extracellularly and intracellularly, with reduced toxicity to mammalian cells.

Drug susceptibility profiling of Australian Burkholderia species as models for developing melioidosis therapeutics

The paper profiles drug susceptibility of Australian Burkholderia species to identify models for developing melioidosis therapeutics, finding high similarity in susceptibility profiles between B. pseudomallei and less pathogenic species.

Comparative genomics confirms a rare melioidosis human-to-human transmission event and reveals incorrect phylogenomic reconstruction due to polyclonality

This paper investigates a rare human-to-human transmission of Burkholderia pseudomallei from mother to child using whole-genome sequencing, revealing polyclonality in the mother and demonstrating how mixture can mislead phylogenomic analysis.

Pathogen to commensal: longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection

This study tracks the long-term evolution of Burkholderia pseudomallei in a human host over 16 years, showing its transition from a pathogen to a commensal through genetic and phenotypic changes.

Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure

This study characterizes the caprine humoral immune response to Burkholderia pseudomallei during aerosol-induced melioidosis, identifying immunogenic proteins that may serve as diagnostic biomarkers.

A Mouse Model Of Binge Alcohol Consumption and Burkholderia Infection

This study shows that binge alcohol consumption increases Burkholderia infection severity by reducing immune function and increasing tissue permeability and bacterial spread.

Development and validation of a triplex qPCR assay to detect efflux pump-mediated antibiotic resistance in Burkholderia pseudomallei

The paper develops and validates a triplex qPCR assay to detect efflux pump upregulation in Burkholderia pseudomallei, correlating with antibiotic resistance.

Transcriptomic analysis of longitudinal Burkholderia pseudomallei infecting the cystic fibrosis lung

This study analyzes transcriptomic changes in Burkholderia pseudomallei isolates from cystic fibrosis patients over time, identifying gene expression patterns linked to adaptation and antibiotic resistance.

Raising the stakes: Loss of efflux-pump regulation decreases meropenem susceptibility in Burkholderia pseudomallei

This study identifies mutations in RND efflux pump regulators in B. pseudomallei isolates that lead to decreased meropenem susceptibility and are associated with fatal melioidosis outcomes.