Author

M. A. Schembri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:E. coli· 6 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Assay:whole-genome sequencing· 3 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M.-D. Phan· 2 shared A. Crowe· 1 shared A. DiAntonio· 1 shared A. E. Whitten· 1 shared A. J. Fraser· 1 shared A. Lo· 1 shared A. M. Wailan· 1 shared A. P. Roberts· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersMicrobiology

M.-D. Phan

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Discovery and characterisation of new phage targeting uropathogenic Escherichia coli

S. A. Kangachar, D. Y. Logel, E. Trofimova, H. X. Zhu, J. Zaugg, M. A. Schembri, K. D. Weynberg, P. R. Jaschke

This study identifies and characterizes six new phages targeting uropathogenic Escherichia coli, showing host range correlation with tail fiber proteins and improved efficacy in mixed infections.

Virology · Sep 1, 2024Peer-reviewedMicrobiology

Molecular mechanisms of re-emerging chloramphenicol susceptibility in extended-spectrum beta-lactamase producing Enterobacterales

F. E. Graf, R. N. Goodman, S. Gallichan, S. Forrest, E. Picton-Barlow, A. J. Fraser, M.-D. Phan, M. Mphasa, A. T. Hubbard, P. Musicha, M. A. Schembri, A. P. Roberts, T. Edwards, J. M. Lewis, N. A. Feasey

The paper investigates the re-emerging chloramphenicol susceptibility in ESBL-producing Enterobacterales by analyzing genotype-phenotype discordance and molecular mechanisms.

bioRxiv · Nov 16, 2023Microbiology

Chemical structures of cyclic ADP ribose (cADPR) isomers and the molecular basis of their production and signaling

M. K. Manik, Y. Shi, S. Li, M. A. Zaydman, N. Damaraju, S. Eastman, T. Smith, W. Gu, V. Masic, T. Mosaiab, J. S. Weagley, S. J. Hancock, E. Vasquez, L. Hartley-Tassell, N. Maruta, , B. Kobe

The paper reports the chemical structures of two cADPR isomers, their production mechanism, and their roles in antiviral signaling and plant immunity suppression.

bioRxiv · May 7, 2022 · PreprintBiochemistry

Modified defence peptides from horseshoe crab target and kill bacteria inside host cells

A. S. Amiss, J. B. von Pein, J. R. Webb, N. D. Condon, P. J. Harvey, M.-D. Phan, M. A. Schembri, B. J. Currie, M. J. Sweet, D. J. Craik, R. Kapetanovic, S. T. Henriques, N. Lawrence

This study identifies modified antimicrobial peptides from horseshoe crabs that effectively kill bacteria, including UPEC, both extracellularly and intracellularly, with reduced toxicity to mammalian cells.

bioRxiv · Jun 27, 2021Microbiology

Fine tuning the mechanism of Antigen 43 self-association to modulate aggregation levels of Escherichia coli pathogens

J. Vo, G. C. Martinez Ortiz, M. Totsika, A. Lo, A. E. Whitten, L. Hor, K. M. Peters, V. Ageorges, N. Caccia, M. Desvaux, M. A. Schembri, J. J. Paxman, B. Heras

The paper investigates the role of Ag43 homologues in bacterial aggregation and biofilm formation, revealing a common trans-association mechanism and how variations in these interactions affect aggregation kinetics.

bioRxiv · Apr 19, 2021 · PreprintBiochemistry

Multiple evolutionary trajectories for non-O157 Shiga toxigenic Escherichia coli

N.-F. Alikhan, N. L. Bachmann, N. L. Ben Zakour, N. K. Petty, M. Stanton-Cook, J. A. Gawthorne, D. M. Easton, T. J. Mahony, R. Cobbold, M. A. Schembri, S. A. Beatson

This study uses whole genome sequencing to analyze 44 non-O157 STEC strains, revealing seven distinct lineages with diverse virulence factors and evolutionary histories.

bioRxiv · Apr 4, 2019 · PreprintMicrobiology

Identification and characterization of a phase-variable element that regulates the autotransporter UpaE in uropathogenic Escherichia coli

R. A. WELCH, K. G. Goh, T. S. Atruksang, K. Schwartz, M. A. Schembri, E. J. Battaglioli

The paper identifies and characterizes a third phase-variable invertible element, ipuS, in UPEC that regulates the expression of the autotransporter UpaE, which contributes to biofilm formation and kidney colonization.

bioRxiv · Jun 27, 2018Microbiology

Dominance of ST131 Escherichia coli carrying blaCTX-M in patients with bloodstream infections caused by cephalosporin-resistant strains in Australia, New Zealand and Singapore: whole genome analysis of isolates from a randomised trial

P. Harris, N. Ben Zakour, L. W. Roberts, A. M. Wailan, H. M. Zowawi, P. A. Tambyah, D. C. Lye, R. Jureen, T. H. Lee, E. Izharuddin, M. Yin, D. Looke, N. Runnegar, B. Rogers, H. Bhally, , D. L. Paterson

The paper characterizes multidrug-resistant Escherichia coli from bloodstream infections in Australia, New Zealand, and Singapore, finding ST131 dominates with blaCTX-M ESBLs, particularly blaCTX-M-15.

bioRxiv · Aug 29, 2017Microbiology