Informing virtual clinical trials of hepatocellular carcinoma with spatial multi-omics analysis of a human neoadjuvant immunotherapy clinical trial
S. Zhang, A. Deshpande, B. K. Verma, H. Wang, H. Mi, L. Yuan, W. J. Ho, E. M. Jaffee, Q. Zhu, R. A. Anders, M. Yarchoan, L. T. Kagohara, E. J. Fertig, A. S. Popel
The paper develops a spatial quantitative systems pharmacology model for virtual clinical trials in HCC, validated with spatial multi-omics data from a neoadjuvant immunotherapy trial.
bioRxiv · Aug 11, 2023 · PreprintBioengineering