Author

L. Danilova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:cell-cell communication· 4 Approach:experimental assay· 4 Approach:deep learning· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2

Frequent Co-Authors

E. J. Fertig· 6 shared E. M. Jaffee· 4 shared L. T. Kagohara· 3 shared M. Yarchoan· 3 shared N. Zaidi· 3 shared D. Gaykalova· 2 shared D. N. Sidiropoulos· 2 shared G. Mo· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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6 shared papersCancer Biology

E. J. Fertig

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Author profile →

7 papers

Recent·Most cited

Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade

D. H. Shu, W. J. Ho, L. T. Kagohara, A. Girgis, S. M. Shin, L. Danilova, J. W. Lee, D. N. Sidiropoulos, S. Mitchell, K. Munjal, K. Howe, K. J. Bendinelli, H. Qi, G. Mo, J. Montagne, , M. Yarchoan

This study examines TLS in HCC treated with neoadjuvant immunotherapy, finding TLS correlate with better outcomes and show distinct morphological and functional features in tumor regression.

bioRxiv · Oct 16, 2023 · PreprintImmunology

SpliceMutr enables pan-cancer analysis of splicing-derived neoantigen burden in tumors

T. Palmer, M. D. Kessler, X. M. Shao, A. Balan, M. Yarchoan, N. Zaidi, T. Y. Lopez-Vidal, A. Saeed, J. Gore, N. Azad, E. Jaffee, A. V. Favorov, V. Anagnostou, R. Karchin, D. Gaykalova, , E. J. Fertig

SpliceMutr quantifies splicing-derived neoantigens across cancers, finding correlations with immune biomarkers and treatment response.

bioRxiv · May 26, 2023Cancer Biology

Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence

S. Zhang, L. Yuan, L. Danilova, G. Mo, Q. Zhu, A. Deshpande, A. T. F. Bell, J. Elisseeff, A. S. Popel, R. A. Anders, E. M. Jaffee, M. Yarchoan, E. J. Fertig, L. T. Kagohara

This study uses spatial transcriptomics to analyze HCC tumors treated with cabozantinib and nivolumab, identifying distinct immune and fibrotic mechanisms linked to response and recurrence.

bioRxiv · Jan 10, 2023Cancer Biology

MLL1 regulates cytokine-driven cell migration and metastasis

P. R. Nair, L. Danilova, E. Gomez-de-Mariscal, D. Kim, R. Fan, A. Munoz-Barrutia, E. J. Fertig, D. Wirtz

This study shows MLL1 promotes cancer metastasis by regulating cytokine secretion and actin dynamics, and its inhibition reduces metastasis when combined with chemotherapy.

bioRxiv · Oct 18, 2022Cancer Biology

Inflammatory Signaling in Pancreatic Cancer Transfers Between a Single-cell RNA Sequencing Atlas and Co-Culture

B. Kinny-Koster, S. Guinn, J. A. Tandurella, J. T. Mitchell, D. N. Sidiropoulos, M. Loth, M. R. Lyman, A. B. Pucsek, T. T. Seppala, C. Cherry, R. Suri, H. Zlomke, J. He, C. L. Wolfgang, J. Yu, , J. W. Zimmerman

This paper integrates single-cell RNA sequencing data with organoid co-cultures to study inflammatory signaling in pancreatic cancer and validates findings through transfer learning and mechanistic experiments.

bioRxiv · Jul 14, 2022 · PreprintCancer Biology

Transfer learning between preclinical models and human tumors identifies conserved NK cell activation signature in anti-CTLA-4 responsive tumors

E. F. Davis-Marcisak, A. A. Fitzgerald, M. D. Kessler, L. Danilova, E. M. Jaffee, N. Zaidi, L. M. Weiner, E. J. Fertig

The paper uses transfer learning to identify a conserved NK cell activation signature in anti-CTLA-4 responsive tumors across preclinical models and humans, showing its clinical relevance.

bioRxiv · May 31, 2020 · PreprintCancer Biology

Epigenetic Regulation of Gene Expression in Cancer: Techniques, Resources, and Analysis

L. Kagohara, G. Stein-O'Brien, D. Kelley, E. Flam, H. Wick, L. Danilova, H. Easwaran, A. Favorov, J. Qian, D. Gaykalova, E. Fertig

This review discusses epigenetic regulation in cancer, focusing on DNA methylation, chromatin structure, and bioinformatics tools for analyzing high-throughput epigenetic data.

bioRxiv · Mar 8, 2017Cancer Biology