A. Sannigrahi

Conformational switch of a peptide provides a novel strategy to design peptide loaded porous organic polymer for Pyroptosis pathway mediated cancer therapy

This paper designs a peptide-loaded porous organic polymer that undergoes a conformational switch in cancer cells, triggering pyroptosis via membrane pore formation.

In vitro reconstitution demonstrates the amyloid-beta mediated myelin membrane deformation

This study shows A{beta}-40 induces myelin membrane tubulation in vitro through binding and aggregation, revealing mechanisms of potential neuronal demyelination in Alzheimer's Disease.

The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS Model

This study shows that Zn absence, not Cu, affects SOD1 membrane attachment and aggregation in an ALS model, linking it to disease progression.

Membrane composition and lipid to protein ratio modulate amyloid kinetics of yeast prion protein

The paper investigates how membrane composition and lipid-to-protein ratio affect the aggregation kinetics of yeast prion protein Sup35, finding biphasic aggregation at optimal lipid concentrations.

Protein induced membrane phase transition facilitates leishmania infection

This study shows that the Leishmania Donovani protein KMP-11 induces membrane phase transition in macrophages, facilitating infection by altering membrane tension and lipid raft structure.