S. Karmakar

Efficient and multiplexed somatic genome editing with Cas12a mice

This study develops transgenic Cas12a mice to enable efficient, multiplexed somatic genome editing for studying complex genetic interactions in vivo.

Curtailed CaSR expression in peripheral blood mononuclear cells is associated with hypertension

The paper investigates reduced CaSR expression in hypertensive models and links it to impaired NO production and altered Ca2+ dynamics.

Human coronavirus OC43 infection remodels Connexin 43 mediated gap junction intercellular communication in vitro

This study shows that OC43 infection reduces Cx43 expression and impairs gap junction communication in A549 cells, suggesting this pathway could be a therapeutic target for human beta-coronaviruses.

Gestures Of Hunger: Uncovering Intentional Gestural Communication In Free-Ranging Hanuman Langurs

This study identifies intentional gestural communication in Hanuman langurs, showing they use learned gestures to request food from humans and adapt this behavior as a foraging strategy.

A Study on multiple isotherms of Cr6+ ions using Brevibacillus brevis US575 isolated from tannery effluents

This study evaluates the biosorption of Cr6+ ions by Brevibacillus brevis US575 from tannery effluents, finding it effective with 74% removal and favorable adsorption characteristics.

DDX5 (p68) orchestrates β-catenin, RelA and SP1 mediated MGMT gene expression: Implication in TMZ chemoresistance

This study identifies DDX5 (p68) as a master regulator of MGMT gene expression through interactions with β-catenin, RelA, and SP1, contributing to TMZ chemoresistance in colon cancer.

A novel role of USP7 in imparting partial EMT state in colorectal cancer through the DDX3X-β-catenin axis

This study identifies USP7 as a key regulator of partial EMT in colorectal cancer by stabilizing DDX3X and enhancing Wnt/β-catenin signaling.

E3 Ubiquitin Ligase CHIP Drives Monoubiquitination-mediated Nuclear Import of Tumor Suppressor PTEN

This study identifies CHIP as a novel E3 ubiquitin ligase that monoubiquitinates PTEN, promoting its nuclear import and enhancing its tumor suppressive functions.

Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis

This study shows that centrin-deficient L. mexicana parasites protect against Old World visceral leishmaniasis in a hamster model by reducing parasite burden and altering cytokine responses.

Skin resident memory cells generated by the L. major centrin gene deleted parasites mediate protective immune response analogous to leishmanization

This study shows that a genetically modified Leishmania vaccine generates skin-resident memory T cells that provide protection similar to leishmanization.

Combinatorial tumor suppressor inactivation efficiently initiates lung adenocarcinoma with therapeutic vulnerabilities

This study identifies RAS/PI3K pathway activation as a common driver in oncogene-negative lung adenocarcinomas and shows these tumors are vulnerable to targeted therapy.

Wnt/β-catenin signaling and p68 conjointly regulate CHIP in colorectal cancer

This study identifies a novel mechanism where Wnt/β-catenin signaling and p68 regulate CHIP expression in colorectal cancer, promoting cell proliferation and migration.

The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS Model

This study shows that Zn absence, not Cu, affects SOD1 membrane attachment and aggregation in an ALS model, linking it to disease progression.

Integrative genome-wide analysis reveals EIF3A as a key downstream regulator of translational repressor protein Musashi 2 (MSI2)

The paper identifies EIF3A as a direct target of MSI2 and shows that MSI2 represses EIF3A translation, which amplifies its effects on the proteome.

Praja1 ubiquitin ligase facilitates degradation of polyglutamine proteins and suppresses polyglutamine-mediated toxicity

This study identifies Praja1 as a ubiquitin ligase that degrades polyglutamine proteins and reduces their toxicity in neurodegenerative diseases.

Preclinical validation of a second generation leishmanization vaccine against vector transmitted fatal visceral leishmaniasis

This study evaluates the protective efficacy of a CRISPR-edited Leishmania major strain against visceral leishmaniasis in hamsters and shows it induces a pro-inflammatory immune response and prevents disease.

Altered food habits? Understanding the feeding preference of free-ranging Grey langur (Semnopithecus entellus) within an urban settlement.

This study examines the feeding preferences of free-ranging grey langurs in an urban setting, finding they prefer urban food items over natural ones due to resource scarcity and human interaction.

Genotypic and antigenic study of SARS-CoV-2 from an Indian isolate.

The paper analyzes the genotypic and antigenic characteristics of an Indian SARS-CoV-2 isolate, identifying its strain and predicting B and T cell epitopes for vaccine design.

A Second Generation Leishmanization Vaccine with a Markerless Attenuated Leishmania major Strain using CRISPR gene editing

This paper describes a CRISPR-edited Leishmania major strain for a second-generation leishmanization vaccine that is marker-free and safe, showing protection in mice comparable to traditional leishmanization.

Protein induced membrane phase transition facilitates leishmania infection

This study shows that the Leishmania Donovani protein KMP-11 induces membrane phase transition in macrophages, facilitating infection by altering membrane tension and lipid raft structure.