C. Clark

Vancomycin impairs macrophage fungal killing by disrupting mitochondrial morphology and function

This study shows vancomycin impairs macrophage fungal killing by disrupting mitochondrial function and morphology, independent of microbiome effects.

Geographic variation in the songs of two closely related song-learning species, Anna's and Costa's hummingbird (Calypte anna, C. costae)

This study examines geographic variation in songs of two hummingbird species, finding that Anna's hummingbirds show population-level song variation while Costa's hummingbirds show minor frequency differences.

The incidence of movement disorders increases with age and contrasts with subtle and limited neuroimaging abnormalities in argininosuccinic aciduria.

This study investigates movement disorders in argininosuccinic aciduria (ASA), finding they increase with age and show specific neuroimaging abnormalities not seen in mouse models.

Elevated Expression of srp RiPPs Across Bacterial Phyla in Marine Sponges

The paper examines transcriptional activity of bacterial communities in marine sponges, finding that less abundant bacterial bins are more transcriptionally active and that srp RiPPs are highly expressed across diverse phyla.

Conserved folding landscape of monomeric initiator caspases

This study examines the folding mechanisms of monomeric initiator caspases, revealing conserved structural features and an evolutionarily conserved mechanism controlling pH-dependent conformational changes.

Sequential unfolding mechanisms of monomeric caspases

This study investigates the folding mechanisms of monomeric caspases from coral species, revealing a conserved folding landscape and pH-dependent conformational changes.

SCIP: a self-paced, community-based summer coding program creates community and increases coding confidence, lessons learned from the pandemic

SCIP provides an online summer coding program for students, enhancing coding confidence and community engagement during the pandemic.

Sequence type diversity amongst antibiotic-resistant bacterial strains is lower than amongst antibiotic-susceptible strains

The paper compares sequence-type diversity between antibiotic-resistant and susceptible bacterial strains across multiple datasets and finds resistant strains are less diverse in most cases.

A multi-omics analysis of glioma chemoresistance using a hybrid microphysiological model of glioblastoma

This study uses a hybrid microphysiological model to analyze glioma chemoresistance and identifies molecular changes associated with resistance mechanisms.

Comparing the folding landscapes of evolutionarily divergent procaspase-3

This study compares the folding landscapes of zebrafish and human effector procaspase-3, showing conserved folding pathways with species-specific intermediate stability.

Engineering a thixotropic and biochemically tunable hyaluronan and collagen bioink for biofabrication of multiple tissue construct types

This paper develops a tunable bioink using collagen and hyaluronan with thixotropic properties and modular ECM components to support multiple tissue types in 3D bioprinting.

Genetic ablation of serotonin receptor 2B improves aortic valve hemodynamics in a high-cholesterol diet mouse model

This study shows genetic ablation of Htr2b reduces hemodynamic indicators of aortic valve stenosis in a mouse model of CAVD, but pharmacological antagonism had no effect.

Remodeling hydrogen bond interactions results in relaxed specificity of Caspase-3

This study shows that changes in hydrogen bonding near the S3 subsite of caspase-3 affect P4 amino acid selection, leading to relaxed specificity in zebrafish caspase-3a compared to caspase-6.

Caspases from Scleractinian Coral Show Unique Regulatory Features

This study identifies and characterizes caspases from disease-sensitive and -resistant corals, revealing unique regulatory features and structural insights into their function.

A dormant sub-population expressing interleukin-1 receptor characterises anti-estrogen resistant ALDH+ breast cancer stem cells

The paper identifies a dormant ALDH+IL1R1+ sub-population in anti-estrogen resistant breast cancer stem cells and links IL1R1 expression to treatment failure.

The importance of neutral over niche processes in structuring Ediacaran early animal communities

This study uses spatial point process analysis to show that neutral processes, not niche processes, dominated the spatial distribution of Ediacaran animal communities.

Pseudomonas aeruginosa inhibits Rhizopus microsporus germination through sequestration of free environmental iron

This study shows that Pseudomonas aeruginosa inhibits Rhizopus microsporus spore germination by sequestering environmental iron through siderophore secretion, reducing host mortality in a zebrafish model.