Author

A. Sekar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 3 Organism:Drosophila· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Leiblich· 3 shared C. Gandy· 3 shared C. Wilson· 3 shared C. C. Mendes· 2 shared D. Goberdhan· 2 shared J. E. E. U. Hellberg· 2 shared M. Wainwright· 2 shared P. Marie· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCell Biology

A. Leiblich

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Investigating the translational value of Periprosthetic Joint Infection (PJI) models to determine the risk and severity of Staphylococcal biofilms.

A. Sekar, Y. Fan, P. Tierney, M. McCanne, P. Jones, F. Malick, D. Kannambadi, K. K. Wannomae, N. Inverardi, J. Yuh, S. Lekkala, O. K. Muratoglu, E. Oral

This study evaluates preclinical models to assess the risk and severity of Staphylococcal biofilms in periprosthetic joint infections and their antibiotic susceptibility.

bioRxiv · Apr 29, 2024Microbiology

Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells

A. Sekar, A. Leiblich, J. E. E. U. Hellberg, D. Sarma, C. C. Mendes, M. S. Wainwright, C. Gandy, D. C. I. Goberdhan, F. C. Hamdy, C. Wilson

This study shows that Rbf/E2F1 and cell cycle regulators control growth and endoreplication in Drosophila secondary cells via steroid-independent EcR signalling, mirroring mechanisms in castration-resistant prostate cancer.

bioRxiv · Mar 27, 2021 · PreprintCell Biology

Role of ERK activation in H. pylori-induced disruption of cell-cell tight junctions

A. Sekar, B. Ho

This study investigates how H. pylori disrupts cell-cell tight junctions by activating the ERK pathway, showing that inhibiting ERK reduces claudin-4 delocalization and preserves barrier function.

bioRxiv · Sep 3, 2020 · PreprintMicrobiology

Drosophila Sex Peptide Controls the Assembly of Lipid Microcarriers in Seminal Fluid

M. Wainwright, C. C. Mendes, A. Sekar, B. Kroeger, J. E. E. U. Hellberg, S.-J. Fan, A. Pavey, P. Marie, A. Leiblich, C. Gandy, L. Corrigan, R. S. Patel, S. Wigby, J. F. Morris, D. Goberdhan, C. Wilson

This paper shows that Sex Peptide in Drosophila is essential for assembling lipid microcarriers in seminal fluid, which are transferred to females and disassembled, with SP also required for normal female disassembly.

bioRxiv · Apr 24, 2020Cell Biology

Mating Induces Switch From Hormone-Dependent to -Independent Steroid Receptor-Mediated Growth in Drosophila Prostate-Like Cells

C. Wilson, A. Leiblich, J. Hellberg, A. Sekar, C. Gandy, S. Redhai, M. Wainwright, P. Marie, D. Goberdhan, F. Hamdy

The paper shows mating triggers a switch from hormone-dependent to hormone-independent steroid receptor-mediated growth in Drosophila prostate-like cells, similar to prostate cancer progression.

bioRxiv · Jan 29, 2019Cell Biology