Author

S.-J. Fan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 5 Assay:proteomics· 5 Research Focus:cell type annotation· 3 Organism:Drosophila· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 1

Frequent Co-Authors

A. L. Harris· 5 shared C. Wilson· 5 shared M. Wainwright· 4 shared C. C. Mendes· 3 shared D. Goberdhan· 3 shared K. McCormick· 3 shared P. Marie· 3 shared B. Kroeger· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersCancer Biology

A. L. Harris

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

APP and β-amyloid modulate protein aggregation and dissociation from recycling endosomal and exosomal membranes

P. J. Singh, B. Verma, A. Wells, C. C. Mendes, D. Dunn, Y.-N. Chen, J. Oh, L. Blincowe, M. Wainwright, R. Fischer, S.-J. Fan, A. L. Harris, D. C. Goberdhan, C. Wilson

The paper shows APP and Aβ-peptides modulate protein aggregation and DCG biogenesis in Drosophila cells, with mutant Aβ-peptides disrupting these processes and causing AD-like pathologies.

bioRxiv · Mar 28, 2024 · PreprintCell Biology

Stress-induced Rab11a-exosomes induce AREG-mediated cetuximab resistance in colorectal cancer

J. D. Mason, E. Marks, S.-J. Fan, K. McCormick, C. Wilson, A. L. Harris, F. C. Hamdy, C. Cunningham, D. C. I. Goberdhan

This paper shows that stress-induced Rab11a-exosomes carrying AREG promote cetuximab resistance in colorectal cancer by activating EGFR signaling in KRAS-wild type cells.

bioRxiv · Dec 19, 2023 · PreprintCancer Biology

Anti-androgens induce Rab11a-exosome secretion in prostate cancer by suppressing amino acid-sensitive PAT4-mTORC1 signalling

K. McCormick, P. Sanitt, S.-J. Fan, J. D. Mason, A. L. Harris, F. Hamdy, C. Verrill, R. J. Bryant, D. C. I. Goberdhan

This study shows anti-androgens increase Rab11a-exosome secretion in prostate cancer by inhibiting PAT4-mTORC1 signaling, contributing to drug resistance.

bioRxiv · Sep 18, 2020 · PreprintCancer Biology

Accessory ESCRT-III proteins selectively regulate Rab11-exosome biogenesis in Drosophila secondary cells

P. Marie, S.-J. Fan, C. C. Mendes, M. Wainwright, A. L. Harris, D. Goberdhan, C. Wilson

This study identifies accessory ESCRT-III proteins as essential for Rab11-exosome biogenesis in Drosophila secondary cells, distinct from core ESCRT functions.

bioRxiv · Jun 18, 2020 · PreprintCell Biology

Drosophila Sex Peptide Controls the Assembly of Lipid Microcarriers in Seminal Fluid

M. Wainwright, C. C. Mendes, A. Sekar, B. Kroeger, J. E. E. U. Hellberg, S.-J. Fan, A. Pavey, P. Marie, A. Leiblich, C. Gandy, L. Corrigan, R. S. Patel, S. Wigby, J. F. Morris, D. Goberdhan, C. Wilson

This paper shows that Sex Peptide in Drosophila is essential for assembling lipid microcarriers in seminal fluid, which are transferred to females and disassembled, with SP also required for normal female disassembly.

bioRxiv · Apr 24, 2020Cell Biology

Glutamine deprivation regulates the origin and function of cancer cell exosomes

D. Goberdhan, S.-J. Fan, B. Kroeger, P. Marie, E. Bridges, J. Mason, K. McCormick, C. Zois, H. Sheldon, N. Khalid Alham, E. Johnson, M. Elis, I. Stefana, C. Mendes, M. Wainwright, , C. Wilson

This study shows that glutamine deprivation increases exosome release from cancer cells, which promote tumor growth and blood vessel networks through Rab11a-dependent mechanisms.

bioRxiv · Dec 2, 2019Cancer Biology