Author

A. Selmecki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Organism:C. elegans· 3 Assay:whole-genome sequencing· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:fungi (other)· 1 Assay:proteomics· 1

Frequent Co-Authors

L. S. Burrack· 2 shared N. Soisangwan· 2 shared N. V. Solis· 2 shared S. G. Filler· 2 shared A. Buscaino· 1 shared A. Hilk· 1 shared A. K. Beach· 1 shared B. M. Hogan· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

L. S. Burrack

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Erg251 has complex and pleiotropic effects on azole susceptibility, filamentation, and stress response phenotypes

X. Zhou, A. Hilk, N. V. Solis, B. M. Hogan, T. A. Bierbaum, S. G. Filler, L. S. Burrack, A. Selmecki

This study identifies ERG251 mutations that confer azole tolerance and pleiotropic effects on stress responses and filamentation in C. albicans.

bioRxiv · Mar 6, 2024 · PreprintMicrobiology

Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans.

P. V. Zande, C. Gautier, N. Kawar, C. Maufrais, K. Metzner, E. Wash, A. K. Beach, R. Bracken, E. I. Maciel, C. M. Fernandes, N. V. Solis, M. Del Poeta, S. G. Filler, J. Berman, I. V. Ene, A. Selmecki

This study shows how azole resistance in Candida albicans evolves through copy number variation followed by KSR1 loss of heterozygosity, resulting in a >500-fold resistance increase.

bioRxiv · Mar 5, 2024 · PreprintMicrobiology

Genomic diversity across Candida auris clinical isolates shapes rapid development of antifungal resistance in vitro and in vivo

L. S. Burrack, R. T. Todd, N. Soisangwan, N. P. Wiederhold, A. Selmecki

This study shows that genomic diversity in Candida auris isolates leads to rapid in vitro and in vivo development of antifungal resistance through multiple evolutionary pathways.

bioRxiv · Mar 25, 2022Microbiology

The SUMO protease Ulp2 regulates genome stability and drug resistance in the human fungal pathogen Candida albicans

M. Rizzo, N. Soisangwan, J. Soetaert, S. Vega-Estevez, A. Selmecki, A. Buscaino

This study identifies Ulp2 as a regulator of genome stability and drug resistance in C. albicans, showing that its deletion increases genome instability and adaptive potential under antifungal stress.

bioRxiv · Dec 6, 2021 · PreprintMicrobiology